Changes in the vascular reactivity of the isolated tail arteries of spontaneous and renovascular hypertensive rats to endogenous and exogenous noradrenaline.

Détails

ID Serval
serval:BIB_23B32FCD3CE5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Changes in the vascular reactivity of the isolated tail arteries of spontaneous and renovascular hypertensive rats to endogenous and exogenous noradrenaline.
Périodique
Blood Vessels
Auteur(s)
Fouda A.K., Marazzi A., Boillat N., Sonnay M., Guillain H., Atkinson J.
ISSN
0303-6847 (Print)
ISSN-L
0303-6847
Statut éditorial
Publié
Date de publication
1987
Volume
24
Numéro
1-2
Pages
63-75
Langue
anglais
Notes
Publication types: In Vitro ; Journal Article ; Research Support, Non-U.S. Gov't
Résumé
We have investigated the changes in the responses to noradrenaline of isolated tail arteries of spontaneously hypertensive (SHR) and renovascular hypertensive rats (Wistar-Kyoto: two-kidney, one-clip model, WKY:2K1C) compared with normotensive (Wistar-Kyoto, WKY) rats. Renovascular hypertension was induced by 4 weeks' unilateral renal artery clipping. Arteries were vasoconstricted with exogenous noradrenaline, electrical field stimulation or high potassium. The effects of the latter two stimuli were abolished by reserpine and so were presumably dependent on the presence of endogenous noradrenaline. In the SHR the maximal vasoconstriction produced by all three stimuli was greater than in WKY. Dose-response curves were steeper and there was no change in threshold. Vascular mass was greater. We interpret these results as showing an increase in vascular reactivity in the SHR caused by structural adaptation. The WKY:2K1C responses to noradrenaline could also be explained in terms of structural adaptation but there was no increase in vascular mass. Sensitivity to potassium and electrical stimulation was decreased, suggesting a defect in vascular neurotransmission. This was supported by the observations of a decreased arterial noradrenaline content and of decreased sensitivity to cocaine.
Mots-clé
Animals, Arteries/drug effects, Arteries/physiopathology, Blood Pressure/drug effects, Electric Stimulation, Heart Rate/drug effects, Hypertension/physiopathology, Hypertension, Renovascular/physiopathology, Norepinephrine/pharmacology, Norepinephrine/physiology, Potassium/pharmacology, Rats, Rats, Inbred SHR, Rats, Inbred WKY, Tail/blood supply, Vasoconstriction/drug effects
Pubmed
Web of science
Création de la notice
08/09/2011 22:13
Dernière modification de la notice
03/03/2018 14:55
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