Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs).

Détails

ID Serval
serval:BIB_236A0BDABB94
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Evolutionary discrimination of mammalian conserved non-genic sequences (CNGs).
Périodique
Science
Auteur(s)
Dermitzakis E.T., Reymond A., Scamuffa N., Ucla C., Kirkness E., Rossier C., Antonarakis S.E.
ISSN
1095-9203 (Electronic)
ISSN-L
0036-8075
Statut éditorial
Publié
Date de publication
2003
Volume
302
Numéro
5647
Pages
1033-1035
Langue
anglais
Résumé
Analysis of the human and mouse genomes identified an abundance of conserved non-genic sequences (CNGs). The significance and evolutionary depth of their conservation remain unanswered. We have quantified levels and patterns of conservation of 191 CNGs of human chromosome 21 in 14 mammalian species. We found that CNGs are significantly more conserved than protein-coding genes and noncoding RNAS (ncRNAs) within the mammalian class from primates to monotremes to marsupials. The pattern of substitutions in CNGs differed from that seen in protein-coding and ncRNA genes and resembled that of protein-binding regions. About 0.3% to 1% of the human genome corresponds to a previously unknown class of extremely constrained CNGs shared among mammals.
Mots-clé
Animals, Base Sequence, Chromosomes, Human, Pair 21/genetics, Chromosomes, Mammalian/genetics, Conserved Sequence, DNA, Intergenic/genetics, Discriminant Analysis, Evolution, Molecular, Female, Genetic Code, Genome, Humans, Male, Mammals/genetics, Molecular Sequence Data, Polymerase Chain Reaction, Proteins/genetics, RNA, Untranslated/genetics, Selection, Genetic, Sequence Alignment, Species Specificity, Time, Transcription, Genetic
Pubmed
Web of science
Création de la notice
24/01/2008 15:52
Dernière modification de la notice
20/08/2019 13:01
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