Influence of recent immobilization or surgery on mortality in cancer patients with venous thromboembolism.
Details
Serval ID
serval:BIB_2358F1E483ED
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Influence of recent immobilization or surgery on mortality in cancer patients with venous thromboembolism.
Journal
Thrombosis Research
Working group(s)
RIETE Investigators
Contributor(s)
Monreal M., Decousus H., Prandoni P., Brenner B., Barba R., Di Micco P., Bertoletti L., Schellong S., Papadakis M., Tzoran I., Reis A., Bosevski M., Bounameaux H., Malý R., Adarraga MD., Arcelus JI., Ballaz A., Barba R., Barrón M., Barrón-Andrés B., Bascuñana J., Blanco-Molina A., Bueso T., Casado I., Castejón N., Conget F., del Molino F., del Toro J., Falgá C., Fernández-Capitán C., Font L., Fuentes MI., Gallego P., García-Bragado F., García-Lorenzo MD., Gómez V., González J., González-Bachs E., Grau E., Guil M., Gutiérrez J., Hernández L., Hernández-Huerta S., Jaras MJ., Jiménez D., Lecumberri R., Lobo JL., López-Jiménez L., López-Montes L., López-Reyes R., López-Sáez JB., Lorente MA., Lorenzo A., Luque JM., Madridano O., Marchena PJ., Martín M., Monreal M., Nauffal D., Nieto JA., Núñez MJ., Ogea JL., Pedrajas JM., Peris ML., Porras JA., Riera-Mestre A., Rivas A., Rodríguez-Dávila MA., Román P., Roncero A., Rosa V., Ruiz-Giménez N., Ruiz J., Sahuquillo JC., Samperiz A., Sánchez Muñoz-Torrero JF. , Soler S., Suriñach JM., Tiberio G., Tolosa C., Trujillo-Santos J., Uresandi F., Valdés M., Valero B., Valle R., Vela J., Vidal G., Villalta J., Verhamme P., Peerlinck K., Gadelha T., Ribeiro R., Vassalo J., Wells P., Malý R., Hirmerova J., Kaletova M., Tomko T., Bertoletti L., Bura-Riviere A., Farge-Bancel D., Hij A., Mahe I., Merah A., Schellong S., Babalis D., Papadakis M., Tzinieris I., Braester A., Brenner B., Tzoran I., Zeltser D., Amitrano M., Barillari G., Ciammaichella M., Di Micco P., Duce R., Giorgi-Pierfranceschi M., Maida R., Prandoni P., Quintavalla R., Rocci A., Rota L., Tiraferri E., Tonello D., Tufano A., Visonà A., Zalunardo B., Sá Bastos M., Sousa MS., Rei R., Bosevski M., Kovacevic D., Bounameaux H., Mazzolai L.
ISSN
1879-2472 (Electronic)
ISSN-L
0049-3848
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
133
Number
Suppl 2
Pages
S29-S34
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
BACKGROUND: The influence of recent immobilization or surgery on mortality in cancer patients with venous thromboembolism (VTE) has not been thoroughly studied.
METHODS: We used the RIETE Registry data to compare the 3-month mortality rate in cancer patients with VTE, with patients categorized according to the presence of recent immobilization, surgery or neither. The major outcomes were fatal pulmonary embolism (PE) and fatal bleeding within the first 3 months.
RESULTS: Of 6,746 patients with active cancer and acute VTE, 1,224 (18%) had recent immobilization, 1,055 (16%) recent surgery, and 4,467 (66%) had neither. The all-cause mortality was 23.4% (95% CI: 22.4-24.5), and the PE-related mortality: 2.5% (95% CI: 2.1-2.9). Four in every ten patients dying of PE had recent immobilization (37%) or surgery (5.4%). Only 28% of patients with immobilization had received prophylaxis, as compared with 67% of the surgical. Fatal PE was more common in patients with recent immobilization (5.0%; 95% CI: 3.9-6.3) than in those with surgery (0.8%; 95% CI: 0.4-1.6) or neither (2.2%; 95% CI: 1.8-2.6). On multivariate analysis, patients with immobilization were at an increased risk for fatal PE (odds ratio: 1.8; 95% CI: 1.2-2.5).
CONCLUSIONS: One in every three cancer patients dying of PE had recent immobilization for ≥ 4 days. Many of these deaths could have been prevented with adequate thromboprophylaxis.
METHODS: We used the RIETE Registry data to compare the 3-month mortality rate in cancer patients with VTE, with patients categorized according to the presence of recent immobilization, surgery or neither. The major outcomes were fatal pulmonary embolism (PE) and fatal bleeding within the first 3 months.
RESULTS: Of 6,746 patients with active cancer and acute VTE, 1,224 (18%) had recent immobilization, 1,055 (16%) recent surgery, and 4,467 (66%) had neither. The all-cause mortality was 23.4% (95% CI: 22.4-24.5), and the PE-related mortality: 2.5% (95% CI: 2.1-2.9). Four in every ten patients dying of PE had recent immobilization (37%) or surgery (5.4%). Only 28% of patients with immobilization had received prophylaxis, as compared with 67% of the surgical. Fatal PE was more common in patients with recent immobilization (5.0%; 95% CI: 3.9-6.3) than in those with surgery (0.8%; 95% CI: 0.4-1.6) or neither (2.2%; 95% CI: 1.8-2.6). On multivariate analysis, patients with immobilization were at an increased risk for fatal PE (odds ratio: 1.8; 95% CI: 1.2-2.5).
CONCLUSIONS: One in every three cancer patients dying of PE had recent immobilization for ≥ 4 days. Many of these deaths could have been prevented with adequate thromboprophylaxis.
Pubmed
Web of science
Create date
28/11/2014 15:40
Last modification date
20/08/2019 13:01
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