Blood, urine and vitreous isopropyl alcohol as biochemical markers in forensic investigations.

Détails

ID Serval
serval:BIB_2351EB25E648
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Blood, urine and vitreous isopropyl alcohol as biochemical markers in forensic investigations.
Périodique
Legal Medicine
Auteur(s)
Palmiere C., Sporkert F., Werner D., Bardy D., Augsburger M., Mangin P.
ISSN
1344-6223
1873-4162 (Electronic)
ISSN-L
1344-6223
Statut éditorial
Publié
Date de publication
2012
Volume
14
Numéro
1
Pages
17-20
Langue
anglais
Notes
Publication types: Journal Article
Résumé
Isopropyl alcohol (IPA) is widely used as an industrial solvent and cleaning fluid. After ingestion or absorption, IPA is converted into acetone by alcohol dehydrogenase. However, in ketosis, acetone can be reduced to IPA. The aim of this study was to investigate blood IPA and acetone concentrations in a series of 400 medico-legal autopsies, including cases of diabetic ketoacidosis, hypothermia and alcohol misuse-related deaths, to illustrate the extent of ketosis at the time of death. Vitreous glucose, blood 3-β-hydroxybutyrate (3HB) and acetoacetate (AcAc) concentrations were also determined systematically. Additionally, vitreous and urine IPA, acetone, 3HB and AcAc concentrations as well as other biochemical markers, including glycated hemoglobin and carbohydrate-deficient transferrin (CDT) were also determined in selected cases. The results of this study indicate that ketosis is characterized by the presence of IPA resulting from the acetone metabolism and that IPA can be detected in several substrates. These findings confirm the importance of the systematic determination of IPA and acetone levels that is used to quantify biochemical disturbances and the importance of ketosis at the time of death.
Mots-clé
2-Propanol/analysis, 3-Hydroxybutyric Acid/analysis, Acetoacetates/analysis, Acetone/analysis, Biological Markers/analysis, Case-Control Studies, Flame Ionization, Forensic Pathology, Glucose/analysis, Hemoglobin A, Glycosylated/analysis, Humans, Hypothermia/metabolism, Ketosis/metabolism, Postmortem Changes, Transferrin/analogs & derivatives, Transferrin/analysis, Vitreous Body/chemistry
Pubmed
Web of science
Création de la notice
01/03/2012 15:41
Dernière modification de la notice
20/08/2019 13:00
Données d'usage