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Intervention du système calcium-calmoduline dans la libération de l'hormone de croissance provoquée par la somatocrinine [Intervention of the calcium-calmodulin system in the release of growth hormone induced by somatocrinin]
This study was carried out to evaluate the role of the calcium-calmodulin system in cellular mediation of somatocrinin action by cells producing growth hormone. We compared GH release to intra- and extracellular cAMP levels, after incubation of pituitary cells in monolayer culture with somatocrinin alone or somatocrinin associated with exogenous calmodulin, or specific calmodulin inhibitor (W13). Calmodulin (10(-6) M) decreases somatocrinin - induced cAMP levels, maintaining elevated GH levels. W13 (10(-5) M) increases somatocrinin - induced cAMP and GH levels. Thus GH release induced by somatocrinin is modulated by two interrelated systems, adenylcyclase - cAMP system and Ca++-calmodulin system.
Animals, Calcium/physiology, Calmodulin/physiology, Cells, Cultured, Cyclic AMP/metabolism, Female, Growth Hormone/metabolism, Growth Hormone-Releasing Hormone/pharmacology, Peptide Fragments/pharmacology, Pituitary Gland, Anterior/drug effects, Pituitary Gland, Anterior/metabolism, Rats, Rats, Inbred Strains, Sulfonamides/pharmacology
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