Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Primary clear cell sarcoma of the ileum: an uncommon and misleading site
PT - Case Reports PT - Journal Article
A clear cell sarcoma, arising primarily in the ileum of a 35-year-old man, is reported. Histologically, the neoplasm infiltrated the full thickness of the intestinal wall. It consisted of strands and sheets of round to spindle-shaped cells with clear to eosinophilic cytoplasm, vesicular nuclei and prominent nucleoli. Vascular invasion was present at diagnosis. Tumour cells expressed S-100 protein, melan-A and tyrosinase. They were negative for HMB45, CD117, cytokeratins, epithelial membrane antigen, smooth muscle actin, desmin, CD31, CD34, chromogranin and synaptophysin. Reverse transcription-polymerase chain reaction analysis performed on paraffin-embedded tissue showed EWS-ATF1 fusion transcripts representative of the t(12;22) (q13;q12) clear cell sarcoma reciprocal translocation. The patient, who developed liver metastases 2 months after diagnosis, died of disease at 15 months. This case demonstrates that the gastrointestinal tract is a potential site for primary clear cell sarcoma of soft tissues, and, furthermore, that cytogenetics and/or molecular techniques play a central role in the diagnosis
Adult/Fatal Outcome/Humans/Ileal Neoplasms/genetics/metabolism/Pathology/Immunohistochemistry/Liver Neoplasms/secondary/Male/Oncogene Proteins,Fusion/Reverse Transcriptase Polymerase Chain Reaction/Sarcoma,Clear Cell/Tumor Markers,Biological/analysis
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