Impact of transient correction of increased adrenocortical activity in hypothalamo-damaged, hyperadipose female rats.

Détails

ID Serval
serval:BIB_232F007BD66C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Impact of transient correction of increased adrenocortical activity in hypothalamo-damaged, hyperadipose female rats.
Périodique
International Journal of Obesity
Auteur(s)
Moreno G., Perelló M., Camihort G., Luna G., Console G., Gaillard R.C., Spinedi E.
ISSN
0307-0565
Statut éditorial
Publié
Date de publication
01/2006
Peer-reviewed
Oui
Volume
30
Numéro
1
Pages
73-82
Langue
anglais
Notes
Publication types: Journal Article
Résumé
OBJECTIVE: To explore the effects of transient correction of enhanced corticoadrenal activity in monosodium L-glutamate (MSG)-damaged female rats on peripheral insulin sensitivity and in vitro retroperitoneal (RP) adipocyte function. DESIGNS: A dose of 4 mg/g body weight (BW) of MSG or vehicle (CTR) was i.p. injected, once every 2 days, between days 2 and 10 of age, in female rats. Intact and 21 day-operated (sham or adrenal enucleation (AE)) rats from both (CTR and MSG) groups were used for experimentation on day 120 of age. Circulating levels of several hormones, in basal and after i.v. high-glucose load conditions, and RP adiposity morphology and function were then evaluated. RESULTS: MSG rats developed increased adrenocortical function, hyperadiposity, hyperleptinemia, hyperinsulinemia and decreased peripheral insulin sensitivity. These characteristics were fully reversed after transient correction of corticoadrenal hyperactivity induced by AE. In addition, in vitro experimentation with isolated RP adipocytes indicated that cells from intact MSG animals displayed decreased sensitivity to insulin and dexamethasone stimulation of leptin secretion. Interestingly, adipocyte dysfunction in MSG rats was fully abrogated after AE-induced transient correction of insulinemia, leptinemia and adrenocortical activity. Importantly, the reversion of these metabolic abnormalities, induced by AE for 21 days, in MSG animals did occur, despite no significant changes in BW values. CONCLUSION: Our results support that the changes in adipocyte characteristics and peripheral insulin resistance, developed in this pseudo-obese female rat model, are mainly due to increased glucocorticoid production. Importantly, appropriate correction of the enhanced adrenocortical activity fully reversed these abnormal functions.
Mots-clé
Adipocytes/drug effects, Adipocytes/pathology, Adipose Tissue/pathology, Adipose Tissue/physiopathology, Adiposity/physiology, Adrenal Cortex/physiopathology, Animals, Blood Glucose/metabolism, Cells, Cultured, Corticosterone/blood, Dexamethasone/pharmacology, Female, Glucocorticoids/biosynthesis, Hypothalamic Diseases/chemically induced, Hypothalamic Diseases/complications, Insulin/blood, Insulin/pharmacology, Insulin Resistance/physiology, Leptin/blood, Male, Obesity/etiology, Obesity/pathology, Rats, Rats, Sprague-Dawley, Sodium Glutamate
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/02/2008 17:57
Dernière modification de la notice
08/05/2019 15:46
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