Article: article from journal or magazin.
Adenosine increases an internal calcium store in the smooth muscle of guinea-pig taenia coli
European Journal of Pharmacology
In Vitro Journal Article Research Support, Non-U.S. Gov't --- Old month value: Mar 26
The effect of adenosine on an internal calcium store which can be released by carbachol to produce a transient contraction in Ca2+-free solution was investigated in the taenia depolarized by high K+. The carbachol contraction in Ca2+-free solution was increased by the preceding application of adenosine (3 X 10(-5) to 10(-3) M), an effect which was mimicked by ATP, but not by the slowly degradable analog alpha, beta-methylene ATP. The P1-purinoceptor antagonist 8-phenyltheophylline inhibited the increase caused by adenosine without modifying the carbachol contraction in controls. It is concluded that stimulation of an extracellular P1-purinoceptor increases an internal store of calcium, which might contribute to the relaxation induced by adenosine in the taenia.
Adenosine/*pharmacology Adenosine Triphosphate/pharmacology Animals Calcium/*metabolism Egtazic Acid/pharmacology Female Guinea Pigs Intestines/*drug effects/metabolism Male Muscle Contraction/drug effects Muscle, Smooth/*drug effects/metabolism/physiology Receptors, Neurotransmitter/drug effects Receptors, Purinergic
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