Changes of motor corticobulbar projections following different lesion types affecting the central nervous system in adult macaque monkeys.

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License: CC BY 4.0
Serval ID
serval:BIB_22EBB5B3B754
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Changes of motor corticobulbar projections following different lesion types affecting the central nervous system in adult macaque monkeys.
Journal
The European journal of neuroscience
Author(s)
Fregosi M., Contestabile A., Badoud S., Borgognon S., Cottet J., Brunet J.F., Bloch J., Schwab M.E., Rouiller E.M.
ISSN
1460-9568 (Electronic)
ISSN-L
0953-816X
Publication state
Published
Issued date
08/2018
Peer-reviewed
Oui
Volume
48
Number
4
Pages
2050-2070
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Functional recovery from central nervous system injury is likely to be partly due to a rearrangement of neural circuits. In this context, the corticobulbar (corticoreticular) motor projections onto different nuclei of the ponto-medullary reticular formation (PMRF) were investigated in 13 adult macaque monkeys after either, primary motor cortex injury (MCI) in the hand area, or spinal cord injury (SCI) or Parkinson's disease-like lesions of the nigro-striatal dopaminergic system (PD). A subgroup of animals in both MCI and SCI groups was treated with neurite growth promoting anti-Nogo-A antibodies, whereas all PD animals were treated with autologous neural cell ecosystems (ANCE). The anterograde tracer BDA was injected either in the premotor cortex (PM) or in the primary motor cortex (M1) to label and quantify corticobulbar axonal boutons terminaux and en passant in PMRF. As compared to intact animals, after MCI the density of corticobulbar projections from PM was strongly reduced but maintained their laterality dominance (ipsilateral), both in the presence or absence of anti-Nogo-A antibody treatment. In contrast, the density of corticobulbar projections from M1 was increased following opposite hemi-section of the cervical cord (at C7 level) and anti-Nogo-A antibody treatment, with maintenance of contralateral laterality bias. In PD monkeys, the density of corticobulbar projections from PM was strongly reduced, as well as that from M1, but to a lesser extent. In conclusion, the densities of corticobulbar projections from PM or M1 were affected in a variable manner, depending on the type of lesion/pathology and the treatment aimed to enhance functional recovery.
Keywords
Parkinson, anterograde tracing, brainstem, cortical lesion, motor cortex, non-human primate, spinal cord injury, nonhuman primate
Pubmed
Web of science
Open Access
Yes
Create date
31/07/2018 14:35
Last modification date
20/08/2019 13:00
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