Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_22E8702B02A0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dependence of brain intravoxel incoherent motion perfusion parameters on the cardiac cycle.
Périodique
Plos One
Auteur(s)
Federau C., Hagmann P., Maeder P., Müller M., Meuli R., Stuber M., O'Brien K.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
8
Numéro
8
Pages
e72856
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Measurement of microvascular perfusion with Intravoxel Incoherent Motion (IVIM) MRI is gaining interest. Yet, the physiological influences on the IVIM perfusion parameters ("pseudo-diffusion" coefficient D*, perfusion fraction f, and flow related parameter fD*) remain insufficiently characterized. In this article, we hypothesize that D* and fD*, which depend on blood speed, should vary during the cardiac cycle. We extended the IVIM model to include time dependence of D* = D*(t), and demonstrate in the healthy human brain that both parameters D* and fD* are significantly larger during systole than diastole, while the diffusion coefficient D and f do not vary significantly. The results non-invasively demonstrate the pulsatility of the brain's microvasculature.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/10/2013 9:03
Dernière modification de la notice
20/08/2019 13:00
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