The immunological synapse and actin assembly: a regulatory role for PKC theta.

Details

Serval ID
serval:BIB_22993368F1BB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The immunological synapse and actin assembly: a regulatory role for PKC theta.
Journal
Developmental Cell
Author(s)
Thome M.
ISSN
1534-5807[print], 1534-5807[linking]
Publication state
Published
Issued date
2003
Volume
4
Number
1
Pages
3-5
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Engagement of the T cell receptor leads to the accumulation of filamentous actin, which is necessary for the formation of the immunological synapse and subsequent T cell activation. In the December issue of Molecular Cell, Sasahara et al. provide new insights into the link between the T cell receptor and actin assembly in the immunological synapse, and reveal a critical regulatory role for PKC theta in this process.
Keywords
Actins/metabolism, Adaptor Proteins, Signal Transducing, Carrier Proteins/metabolism, Immunocompetence, Isoenzymes/metabolism, Lymphocyte Activation, Models, Immunological, Nuclear Proteins/metabolism, Protein Kinase C/metabolism, Proteins/metabolism, Receptors, Antigen, T-Cell/immunology, Signal Transduction, T-Lymphocytes/cytology, T-Lymphocytes/enzymology, Wiskott-Aldrich Syndrome Protein
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 15:11
Last modification date
20/08/2019 13:00
Usage data