Association between cellular response (IL-4) to RESA/Pf155 and protection from clinical malaria among Papua New Guinean children living in a malaria endemic area

Détails

ID Serval
serval:BIB_2296E0A75394
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association between cellular response (IL-4) to RESA/Pf155 and protection from clinical malaria among Papua New Guinean children living in a malaria endemic area
Périodique
Parasite Immunology
Auteur(s)
al-Yaman  F., Genton  B., Taraika  J., Anders  R., Alpers  M. P.
ISSN
0141-9838 (Print)
Statut éditorial
Publié
Date de publication
06/1997
Volume
19
Numéro
6
Pages
249-54
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Jun
Résumé
A prospective study in 207 children aged 0.5-15 years was carried out to examine the relationship between cellular responses to Plasmodium falciparum ring-infected erythrocyte surface antigen (RESA) and malaria infection and morbidity. The prevalence of lymphoproliferative response to RESA was 13%, IFN-gamma prevalence was 40% and IL-4 prevalence was 22%. Only the IFN-gamma, response to RESA increased significantly with age. When proliferation or stimulation of either cytokine was used to assess T-cell activation the overall frequency of responders increased to 55%. The proliferative and IFN-gamma response to RESA were positively associated. Although there was no association between any of the CMI responses to RESA and concurrent morbidity the prevalence of IL-4 response to RESA was significantly lower in children who experienced clinical malaria in the following year. These results coupled with our earlier data showing a negative relationship between humoral responses to RESA and malaria morbidity support the inclusion of RESA in a subunit vaccine against malaria.
Mots-clé
Adolescent Animals Antigens, Protozoan/*immunology Cell Division Cells, Cultured Child Child, Preschool Cohort Studies *Endemic Diseases Humans Infant Interferon Type II/immunology Interleukin-4/*immunology Leukocytes, Mononuclear/cytology Malaria/epidemiology/*immunology Papua New Guinea/epidemiology Plasmodium falciparum/*immunology Prospective Studies Protozoan Proteins/*immunology Recombinant Fusion Proteins/immunology T-Lymphocytes/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:49
Dernière modification de la notice
03/03/2018 14:51
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