Expression of intercellular adhesion molecule 3 (CDw50) on endothelial cells in cutaneous lymphomas. A comparative study between nodal and cutaneous lymphomas

Détails

ID Serval
serval:BIB_224B89EDCAFE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Expression of intercellular adhesion molecule 3 (CDw50) on endothelial cells in cutaneous lymphomas. A comparative study between nodal and cutaneous lymphomas
Périodique
American Journal of Dermatopathology
Auteur(s)
Dommann  S. N., Dommann-Scherrer  C. C., Ziegler  T., Meyer  J., Trueb  R. M., Kundig  T., Panizzon  R., Burg  G.
ISSN
0193-1091 (Print)
Statut éditorial
Publié
Date de publication
08/1997
Volume
19
Numéro
4
Pages
391-5
Notes
Comparative Study
Journal Article --- Old month value: Aug
Résumé
Advances in the molecular definition of surface proteins (adhesion molecules) involved in tumor metastasis may help to explain the invasive behavior of malignant tumors, that is, the migration of tumor cells involving reversible adhesive contacts, their release in the circulation, and their extravasation into distant sites. Intercellular adhesion molecule-3 (ICAM-3), the third receptor for the lymphocyte function-associated antigen molecule-1 (LFA-1) was recently characterized. We investigated fresh frozen skin biopsies from 10 patients with mycosis fungoides, four with pleomorphic T-cell lymphoma, six with Sezary syndrome, 10 with primary cutaneous B-cell lymphoma, and 10 with eczematous lesions as controls. The biopsies were compared with lymph node biopsies of five patients with known cutaneous T-cell lymphoma (CTCL), 10 with primary nodal B-cell lymphoma, and 11 with lymph-node specimens showing dermatopathic lymphadenopathy as controls. The specimens were stained with ICAM-3 antibody (Bender Medical Science) using the alkaline phosphatase antialkaline phosphatase method. Using cytomorphologic criteria, neoplastic lymphocytes could be differentiated from smaller reactive cells. Staining intensities were classified semiquantitatively as follows: 4, strong expression in 75 to 100% of the tumor cells; 3, 50 to 75%; 2, 25 to 50%; 1, 5 to 25%; and 0 fewer than 5% of the tumor cells. The endothelial cells in skin biopsies of seven of 30 primary cutaneous lymphomas expressed ICAM-3. In contrast, no expression of ICAM-3 could be demonstrated on endothelial cells in lymph nodes infiltrated with tumor cells of CTCL. Finally, endothelial cells of lymph nodes infiltrated with primary nodal B-cell lymphomas showed expression of ICAM-3 in three of 10 patients. The endothelial cells in the 11 control patients presenting with both eczematous lesions and dermatopathic lymphadenopathy showed no staining for ICAM-3. Every patient who expressed ICAM-3 on endothelial cells showed systemic spread of this disease. The findings suggest that ICAM-3 expression may be induced on endothelial cells in late-stage cutaneous lymphomas, probably by a cytokine-mediated mechanism.
Mots-clé
Adult Aged Aged, 80 and over Alkaline Phosphatase/diagnostic use *Antigens, CD *Antigens, Differentiation Biopsy Cell Adhesion Molecules/analysis/*genetics Cell Movement Coloring Agents/diagnostic use Eczema/pathology Endothelium/*pathology Female Gene Expression Regulation, Neoplastic Humans Lymph Nodes/*pathology Lymphatic Diseases/pathology Lymphatic Metastasis/pathology Lymphocyte Function-Associated Antigen-1/analysis/genetics Lymphocytes/pathology Lymphoma, B-Cell/pathology Lymphoma, Lymphoblastic/pathology Lymphoma, T-Cell, Cutaneous/*pathology Male Middle Aged Mycosis Fungoides/pathology Neoplasm Circulating Cells/pathology Sezary Syndrome/pathology Skin/pathology Skin Neoplasms/*pathology
Pubmed
Web of science
Création de la notice
25/01/2008 16:55
Dernière modification de la notice
20/08/2019 12:59
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