Manifold Roles of CCR7 and Its Ligands in the Induction and Maintenance of Bronchus-Associated Lymphoid Tissue.

Détails

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Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_222C8B8C2A22
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Manifold Roles of CCR7 and Its Ligands in the Induction and Maintenance of Bronchus-Associated Lymphoid Tissue.
Périodique
Cell reports
Auteur(s)
Fleige H., Bosnjak B., Permanyer M., Ristenpart J., Bubke A., Willenzon S., Sutter G., Luther S.A., Förster R.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
17/04/2018
Peer-reviewed
Oui
Volume
23
Numéro
3
Pages
783-795
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The processes underlying the development and maintenance of tertiary lymphoid organs are incompletely understood. Using a Ccr7 knockout/knockin approach, we show that spontaneous bronchus-associated lymphoid tissue (BALT) formation can be caused by CCR7-mediated migration defects of dendritic cells (DCs) in the lung. Plt/plt mice that lack the CCR7 ligands CCL19 and CCL21-serine do not form BALT spontaneously because lung-expressed CCL21-leucine presumably suffices to maintain steady-state DC egress. However, plt/plt mice are highly susceptible to modified vaccinia virus infection, showing enhanced recruitment of immune cells as well as alterations in CCR7-ligand-mediated lymphocyte egress from the lungs, leading to dramatically enhanced BALT. Furthermore, we identify two independent BALT homing routes for blood-derived lymphocytes. One is HEV mediated and depends on CCR7 and L-selectin, while the second route is via the lung parenchyma and is independent of these molecules. Together, these data provide insights into CCR7/CCR7-ligand-orchestrated aspects in BALT formation.
Mots-clé
Animals, Antibodies, Monoclonal/immunology, Bone Marrow Cells/cytology, Bronchi/cytology, Chemokine CCL19/deficiency, Chemokine CCL19/genetics, Chemokine CCL19/metabolism, Chemokine CCL21/metabolism, Dendritic Cells/cytology, Dendritic Cells/metabolism, L-Selectin/immunology, L-Selectin/metabolism, Ligands, Lung/cytology, Lung/immunology, Lung/metabolism, Lymphocytes/cytology, Lymphocytes/immunology, Lymphocytes/virology, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Fluorescence, Receptors, CCR7/deficiency, Receptors, CCR7/genetics, Receptors, CCR7/metabolism, Vaccinia virus/physiology, BALT, CCL21, CCR7, DCs, HEVs, MVA, plt/plt
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/04/2018 16:40
Dernière modification de la notice
24/09/2019 5:11
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