The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients.

Détails

Ressource 1Télécharger: 28189532_AM.pdf (2129.47 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_22245425C64D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The coupling of low-level auditory dysfunction and oxidative stress in psychosis patients.
Périodique
Schizophrenia research
Auteur(s)
Geiser E., Retsa C., Knebel J.F., Ferrari C., Jenni R., Fournier M., Alameda L., Baumann P.S., Clarke S., Conus P., Do K.Q., Murray M.M.
ISSN
1573-2509 (Electronic)
ISSN-L
0920-9964
Statut éditorial
Publié
Date de publication
12/2017
Peer-reviewed
Oui
Volume
190
Pages
52-59
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Patients diagnosed with schizophrenia often present with low-level sensory deficits. It is an open question whether there is a functional link between these deficits and the pathophysiology of the disease, e.g. oxidative stress and glutathione (GSH) metabolism dysregulation. Auditory evoked potentials (AEPs) were recorded from 21 psychosis disorder patients and 30 healthy controls performing an active, auditory oddball task. AEPs to standard sounds were analyzed within an electrical neuroimaging framework. A peripheral measure of participants' redox balance, the ratio of glutathione peroxidase and glutathione reductase activities (GPx/GR), was correlated with the AEP data. Patients displayed significantly decreased AEPs over the time window of the P50/N100 complex resulting from significantly weaker responses in the left temporo-parietal lobe. The GPx/GR ratio significantly correlated with patients' brain activity during the time window of the P50/N100 in the medial frontal lobe. We show for the first time a direct coupling between electrophysiological indices of AEPs and peripheral redox dysregulation in psychosis patients. This coupling is limited to stages of auditory processing that are impaired relative to healthy controls and suggests a link between biochemical and sensory dysfunction. The data highlight the potential of low-level sensory processing as a trait-marker of psychosis.

Mots-clé
Auditory, Event-related potential (ERP), Glutathione (GSH), Oxidative stress, Psychosis, Schizophrenia
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/02/2017 15:33
Dernière modification de la notice
20/08/2019 13:59
Données d'usage