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The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Aug
The autosomal Booroola fecundity gene (FecB) mutation in sheep increases ovulation rate and litter size, with associated effects on ovarian physiology and hormone profiles. Analysis of segregation in twelve families (379 female progeny) identified linkage between the mutation, two microsatellite markers (OarAE101 and OarHH55, Zmax > 9.0) and epidermal growth factor (EGF) from human chromosome 4q25 (Zmax > 3.0). The marker OarAE101 was linked to secreted phosphoprotein 1 (SPP1, which maps to chromosome 4q21-23 in man) in the test pedigrees and independent families (Zmax > 9.7). The identification of linkage between the FecB mutation and markers from human chromosome 4q is an important step towards further understanding the control of ovulation rates in mammals.
Animals Base Sequence *Chromosome Mapping *Chromosomes, Human, Pair 4 DNA Probes DNA, Satellite/genetics Female Fertility/*genetics Genetic Markers Genotype Humans Linkage (Genetics) Male Molecular Sequence Data *Mutation Oligodeoxyribonucleotides Phenotype Recombination, Genetic Sheep/*genetics
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