Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean).

Détails

ID Serval
serval:BIB_21B382C6A27A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean).
Périodique
Kidney international
Auteur(s)
Bochud M., Elston R.C., Maillard M., Bovet P., Schild L., Shamlaye C., Burnier M.
ISSN
0085-2538
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
67
Numéro
1
Pages
61-9
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
Résumé
BACKGROUND: We estimated the heritability of three measures of glomerular filtration rate (GFR) in hypertensive families of African descent in the Seychelles (Indian Ocean). METHODS: Families with at least two hypertensive siblings and an average of two normotensive siblings were identified through a national hypertension register. Using the ASSOC program in SAGE (Statistical Analysis in Genetic Epidemiology), the age- and gender-adjusted narrow sense heritability of GFR was estimated by maximum likelihood assuming multivariate normality after power transformation. ASSOC can calculate the additive polygenic component of the variance of a trait from pedigree data in the presence of other familial correlations. The effects of body mass index (BMI), blood pressure, natriuresis, along with sodium to potassium ratio in urine and diabetes, were also tested as covariates. RESULTS: Inulin clearance, 24-hour creatinine clearance, and GFR based on the Cockcroft-Gault formula were available for 348 persons from 66 pedigrees. The age- and gender-adjusted correlations (+/- SE) were 0.51 (+/- 0.04) between inulin clearance and creatinine clearance, 0.53 (+/- 0.04) between inulin clearance and Cockcroft-Gault formula and 0.66 (+/- 0.03) between creatinine clearance and Cockcroft-Gault formula. The age- and gender-adjusted heritabilities (+/- SE) of GFR were 0.41 (+/- 0.10) for inulin clearance, 0.52 (+/- 0.13) for creatinine clearance, and 0.82 (+/- 0.09) for Cockcroft-Gault formula. Adjustment for BMI slightly lowered the correlations and heritabilities for all measurements whereas adjustment for blood pressure had virtually no effect. CONCLUSION: The significant heritability estimates of GFR in our sample of families of African descent confirm the familial aggregation of this trait and justify further analyses aimed at discovering genetic determinants of GFR.
Mots-clé
Africa, Creatinine, Female, Glomerular Filtration Rate, Humans, Hypertension, Inulin, Kidney, Kidney Failure, Chronic, Male, Middle Aged, Registries, Risk Factors, Seychelles, Siblings
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 13:55
Dernière modification de la notice
20/08/2019 13:58
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