Implications of pulsatile stretch on growth of saphenous vein and mammary artery smooth muscle

Details

Serval ID
serval:BIB_21AA4C73D974
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Implications of pulsatile stretch on growth of saphenous vein and mammary artery smooth muscle
Journal
Lancet
Author(s)
Predel  H. G., Yang  Z., von Segesser  L., Turina  M., Buhler  F. R., Luscher  T. F.
ISSN
0140-6736
Publication state
Published
Issued date
10/1992
Peer-reviewed
Oui
Volume
340
Number
8824
Pages
878-9
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct 10
Abstract
Internal mammary artery (IMA) coronary bypass grafts have a higher patency than saphenous vein (SV) grafts. Intimal hyperplasia and occlusion of venous grafts result from smooth muscle proliferation. Mechanical factors, such as pulsatile stretch, are potential mediators of this process. Smooth muscle cells from IMA and SV were cultured on deformable membranes and exposed to pulsatile stretch (60 cycles/min). This stimulus increased 3H-thymidine incorporation into venous (a two-fold increase) but not arterial smooth muscle cells after 24 h. Smooth muscle cell numbers from SV, but not IMA, were increased (p less than 0.05) after 6 days of stretch. Thus, pulsatile stretch stimulates smooth muscle cell proliferation in SV, but not IMA, and may contribute to venous bypass graft disease.
Keywords
Cell Division/physiology Cells, Cultured DNA Replication/physiology Humans Mammary Arteries/cytology/*physiology Muscle, Smooth, Vascular/*physiology Reflex, Stretch/*physiology Saphenous Vein/cytology/*physiology Stress, Mechanical
Pubmed
Web of science
Create date
14/02/2008 14:19
Last modification date
20/08/2019 12:58
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