Tumor vascular biomarkers: new opportunities for cancer diagnostics.
Details
Serval ID
serval:BIB_21A3042A073A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Tumor vascular biomarkers: new opportunities for cancer diagnostics.
Journal
Cancer Biomarkers : Section A of Disease Markers
ISSN
1875-8592 (Electronic)
ISSN-L
1574-0153
Publication state
Published
Issued date
2010
Volume
8
Number
4-5
Pages
253-271
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Abstract
Tumor vasculature varies significantly from its normal counterpart and displays unique markers. Recent technological advancements including immunohistochemistry laser-capture microdissection (immuno-LCM), genome-wide high-throughput screening, and proteomics have uncovered a vast array of vascular bed-specific markers that may provide a platform for discovery of new therapeutics directed against various malignancies. However, an essential step in the translation of these markers to clinical application will be the identification of those biomarkers with the highest diagnostic and therapeutic potential. The aim of the current review is to provide a synopsis of recent advancements in the identification of tumor vasculature biomarkers.
Keywords
Angiography, Animals, Blood Vessels/metabolism, Blood Vessels/pathology, Endothelial Cells/metabolism, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Neoplasms/blood supply, Neoplasms/diagnosis, Neovascularization, Pathologic/genetics, Neovascularization, Pathologic/metabolism, Tumor Markers, Biological/genetics, Tumor Markers, Biological/metabolism
Pubmed
Web of science
Create date
14/10/2014 11:43
Last modification date
20/08/2019 12:58
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