Multi-channel MRI segmentation of eye structures and tumors using patient-specific features.

Détails

Ressource 1Télécharger: journal.pone.0173900.pdf (2305.85 [Ko])
Etat: Public
Version: Final published version
ID Serval
serval:BIB_219E56C424E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Multi-channel MRI segmentation of eye structures and tumors using patient-specific features.
Périodique
PloS one
Auteur(s)
Ciller C., De Zanet S., Kamnitsas K., Maeder P., Glocker B., Munier F.L., Rueckert D., Thiran J.P., Bach Cuadra M., Sznitman R.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
12
Numéro
3
Pages
e0173900
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Retinoblastoma and uveal melanoma are fast spreading eye tumors usually diagnosed by using 2D Fundus Image Photography (Fundus) and 2D Ultrasound (US). Diagnosis and treatment planning of such diseases often require additional complementary imaging to confirm the tumor extend via 3D Magnetic Resonance Imaging (MRI). In this context, having automatic segmentations to estimate the size and the distribution of the pathological tissue would be advantageous towards tumor characterization. Until now, the alternative has been the manual delineation of eye structures, a rather time consuming and error-prone task, to be conducted in multiple MRI sequences simultaneously. This situation, and the lack of tools for accurate eye MRI analysis, reduces the interest in MRI beyond the qualitative evaluation of the optic nerve invasion and the confirmation of recurrent malignancies below calcified tumors. In this manuscript, we propose a new framework for the automatic segmentation of eye structures and ocular tumors in multi-sequence MRI. Our key contribution is the introduction of a pathological eye model from which Eye Patient-Specific Features (EPSF) can be computed. These features combine intensity and shape information of pathological tissue while embedded in healthy structures of the eye. We assess our work on a dataset of pathological patient eyes by computing the Dice Similarity Coefficient (DSC) of the sclera, the cornea, the vitreous humor, the lens and the tumor. In addition, we quantitatively show the superior performance of our pathological eye model as compared to the segmentation obtained by using a healthy model (over 4% DSC) and demonstrate the relevance of our EPSF, which improve the final segmentation regardless of the classifier employed.

Mots-clé
Algorithms, Cornea/anatomy & histology, Cornea/diagnostic imaging, Eye/anatomy & histology, Eye/diagnostic imaging, Eye Neoplasms/diagnostic imaging, Eye Neoplasms/pathology, Humans, Imaging, Three-Dimensional/methods, Lens, Crystalline/diagnostic imaging, Magnetic Resonance Imaging/methods, Models, Anatomic, Sclera/anatomy & histology, Sclera/diagnostic imaging, Vitreous Body/anatomy & histology, Vitreous Body/diagnostic imaging
Pubmed
Web of science
Open Access
Oui
Création de la notice
04/04/2017 17:31
Dernière modification de la notice
20/08/2019 12:58
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