Association of CYP3A5 genotypes with blood pressure and renal function in African families.

Détails

ID Serval
serval:BIB_2174105C05DE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association of CYP3A5 genotypes with blood pressure and renal function in African families.
Périodique
Journal of hypertension
Auteur(s)
Bochud M., Eap C.B., Elston R.C., Bovet P., Maillard M., Schild L., Shamlaye C., Burnier M.
ISSN
0263-6352
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
24
Numéro
5
Pages
923-9
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Résumé
OBJECTIVE: Renal cytochrome P450 3A5 (CYP3A5) activity has been associated with blood pressure and salt sensitivity in humans. We determined whether CYP3A5 polymorphisms are associated with ambulatory blood pressure (ABP) and with glomerular filtration rate (GFR) in African families. METHODS: Using a cross-sectional design, 375 individuals from 72 families, each with at least two hypertensive siblings, were recruited through a hypertension register in the Seychelles (Indian Ocean). We analyzed the association between the CYP3A5 alleles (*1, *3, *6 and *7) and ABP, GFR and renal sodium handling (fractional excretion of lithium), from pedigree data, allowing for other covariates and familial correlations. RESULTS: CYP3A5*1 carriers increased their daytime systolic and diastolic ABP with age (0.55 and 0.23 mmHg/year) more than non-carriers (0.21 and 0.04 mmHg/year). CYP3A5*1 had a significant main effect on daytime systolic/diastolic ABP [regression coefficient (SE): -29.6 (10.0)/-8.2 (4.1) mmHg, P = 0.003/0.045, respectively] and this effect was modified by age (CYP3A5*1 x age interactions, P = 0.017/0.018). For night-time ABP, the effect of CYP3A5*1 was modified by urinary sodium excretion, not by age. For renal function, CYP3A5*1 carriers had a 7.6(3.8) ml/min lower GFR (P = 0.045) than non-carriers. Proximal sodium reabsorption decreased with age in non-carriers, but not in CYP3A5*1 carriers (P for interaction = 0.02). CONCLUSIONS: These data demonstrate that CYP3A5 polymorphisms are associated with ambulatory BP, CYP3A5*1 carriers showing a higher age- and sodium- related increase in ABP than non-carriers. The age effect may be due, in part, to the action of CYP3A5 on renal sodium handling.
Mots-clé
Adult, African Continental Ancestry Group, Age Factors, Alleles, Analysis of Variance, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme System, Family, Female, Gene Frequency, Genotype, Glomerular Filtration Rate, Heterozygote, Homozygote, Humans, Kidney, Linear Models, Male, Middle Aged, Polymorphism, Genetic, Retrospective Studies, Sodium, Statistics, Nonparametric
Pubmed
Web of science
Création de la notice
05/02/2008 14:38
Dernière modification de la notice
20/08/2019 13:58
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