Distribution and genesis of the RFRP-producing neurons in the rat brain: comparison with melanin-concentrating hormone- and hypocretin-containing neurons.

Details

Serval ID
serval:BIB_216966851A78
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Distribution and genesis of the RFRP-producing neurons in the rat brain: comparison with melanin-concentrating hormone- and hypocretin-containing neurons.
Journal
Neuropeptides
Author(s)
Legagneux K., Bernard-Franchi G., Poncet F., La Roche A., Colard C., Fellmann D., Pralong F., Risold P.Y.
ISSN
0143-4179 (Print)
ISSN-L
0143-4179
Publication state
Published
Issued date
2009
Volume
43
Number
1
Pages
13-19
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
Prepro-RFRP-containing neurons have recently been described in the mammalian brain. These neurons are only found in the tuberal hypothalamus. In this work, we have provided a detailed analysis of the distribution of cells expressing the RFRP mRNA, and found them in seven anatomical structures of the tuberal hypothalamus. No co-expression with melanin-concentrating hormone (MCH) or hypocretin (Hcrt), that are also described in neurons of the tuberal hypothalamus, was observed. Using the BrdU method, we found that all RFRP cell bodies are generated between E13 and E14. Thus, RFRP neurons form a specific cell population with a complex distribution pattern in the tuberal hypothalamus. However, they are generated in one peak. These observations are discussed with data concerning the distribution and genesis of the MCH and Hcrt cell populations that are also distributed in the tuberal hypothalamus.
Keywords
Animals, Female, Humans, Hypothalamic Hormones/genetics, Hypothalamic Hormones/metabolism, Hypothalamus/cytology, Hypothalamus/embryology, Intracellular Signaling Peptides and Proteins/genetics, Intracellular Signaling Peptides and Proteins/metabolism, Male, Melanins/genetics, Melanins/metabolism, Neurogenesis/physiology, Neurons/cytology, Neurons/metabolism, Neuropeptides/genetics, Neuropeptides/metabolism, Pituitary Hormones/genetics, Pituitary Hormones/metabolism, Protein Precursors/genetics, Protein Precursors/metabolism, Rats, Rats, Long-Evans
Pubmed
Web of science
Create date
13/02/2013 15:03
Last modification date
20/08/2019 12:58
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