Brain abnormalities underlying altered activation in dyslexia: a voxel based morphometry study.

Détails

ID Serval
serval:BIB_20E5757A03E0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Brain abnormalities underlying altered activation in dyslexia: a voxel based morphometry study.
Périodique
Brain
Auteur(s)
Silani G., Frith U., Demonet J.F., Fazio F., Perani D., Price C., Frith C.D., Paulesu E.
ISSN
1460-2156 (Electronic)
ISSN-L
0006-8950
Statut éditorial
Publié
Date de publication
10/2005
Peer-reviewed
Oui
Volume
128
Numéro
Pt 10
Pages
2453-2461
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Voxel-based morphometry was used to assess the consistency among functional imaging and brain morphometry data in developmental dyslexia. Subjects, from three different cultural contexts (UK, France and Italy), were the same as those described in a previous PET activation paper, which revealed a common pattern of reduced activation during reading tasks in the left temporal and occipital lobes. We provide evidence that altered activation observed within the reading system is associated with altered density of grey and white matter of specific brain regions, such as the left middle and inferior temporal gyri and the left arcuate fasciculus. This supports the view that dyslexia is associated with both local grey matter dysfunction and with altered connectivity among phonological/reading areas. The differences were replicable across samples confirming that the neurological disorder underlying dyslexia is the same across the cultures investigated in the study.
Mots-clé
Adult, Brain/pathology, Cerebral Cortex/pathology, Cross-Cultural Comparison, Dyslexia/pathology, Humans, Magnetic Resonance Imaging/methods, Neural Pathways/pathology, Positron-Emission Tomography/methods, Reading, Temporal Lobe/pathology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/03/2013 19:46
Dernière modification de la notice
08/05/2019 15:37
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