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Mls--a retrovirus exploits the immune system.
The identity of minor lymphocytes stimulating (Mls) antigens, endogenous superantigens that can activate, or induce the deletion of, large portions of the T-cell repertoire, has recently been revealed: they are encoded by mouse mammary tumor viruses (MMTV) that have integrated into the germ line as DNA proviruses. As Hans Acha-Orbea and Ed Palmer point out, Mls-mediated modulation may be only the tip of the retrovirus iceberg; already murine leukemia virus (MuLV), with similar superantigen properties, has been discovered.
Amino Acid Sequence, Animals, Gene Expression, Humans, Immune System, Mammary Tumor Virus, Mouse/genetics, Mammary Tumor Virus, Mouse/immunology, Minor Lymphocyte Stimulatory Antigens/genetics, Minor Lymphocyte Stimulatory Antigens/immunology, Molecular Sequence Data, T-Lymphocytes/immunology, Virus Integration/genetics, Virus Integration/immunology
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