Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
The multifactorial nature of hypertension: the greatest challenge for its treatment?
Journal of Hypertension. Supplement
Publication types: Journal Article ; Review
Essential hypertension is a polygenic disease involving a major contribution of various environmental factors. It is therefore not surprising that antihypertensive medications, whatever their mechanism(s) of action, only normalize the blood pressure for a fraction of hypertensive patients when administered as monotherapies. It is unfortunately not possible to predict with any degree of certainty which type of blood pressure-lowering agent is the most appropriate for a given patient. Although very attractive, genetic mapping is not really helpful in selecting a treatment for any individual patient. In most patients the association of two medications having different impacts on the cardiovascular system is necessary to normalize blood pressure. Fixed-low-dose combinations are becoming increasingly popular as first line treatment as they increase the probability of bringing the patient's blood pressure under control while minimizing the incidence of dose-dependent adverse effects.
Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Blood Pressure, Dose-Response Relationship, Drug, Drug Therapy, Combination, Europe, Genetic Heterogeneity, Humans, Hypertension, Treatment Outcome, United States, United States Food and Drug Administration, World Health Organization
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