Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids.

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State: Public
Version: Final published version
Serval ID
serval:BIB_207A9393A30A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids.
Journal
International journal of molecular sciences
Author(s)
Polizzi A., Fouché E., Ducheix S., Lasserre F., Marmugi A.P., Mselli-Lakhal L., Loiseau N., Wahli W., Guillou H., Montagner A.
ISSN
1422-0067 (Electronic)
ISSN-L
1422-0067
Publication state
Published
Issued date
24/04/2016
Peer-reviewed
Oui
Volume
17
Number
10
Pages
1624
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
The liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the liver and activated by a variety of fatty acids, is a critical regulator of hepatic fatty acid catabolism during fasting. The present study compared the influence of dietary fatty acids and fasting on hepatic PPARα-dependent responses. Pparα(-/-) male mice and their wild-type controls were fed diets containing different fatty acids for 10 weeks prior to being subjected to fasting or normal feeding. In line with the role of PPARα in sensing dietary fatty acids, changes in chronic dietary fat consumption influenced liver damage during fasting. The changes were particularly marked in mice fed diets lacking essential fatty acids. However, fasting, rather than specific dietary fatty acids, induced acute PPARα activity in the liver. Taken together, the data imply that the potent signalling involved in triggering PPARα activity during fasting does not rely on essential fatty acid-derived ligand.

Keywords
Alanine Transaminase/blood, Animals, Aspartate Aminotransferases/blood, Body Weight, Cholesterol/blood, Cytochrome P-450 Enzyme System/genetics, Cytochrome P450 Family 4/genetics, Dietary Fats, Fasting, Fatty Liver/metabolism, Fatty Liver/pathology, Fibroblast Growth Factors/genetics, Liver/metabolism, Liver/pathology, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, PPAR alpha/genetics, PPAR alpha/metabolism, RNA, Messenger/metabolism, Triglycerides/blood
Pubmed
Open Access
Yes
Create date
29/09/2016 17:26
Last modification date
20/08/2019 12:56
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