The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network.

Details

Serval ID
serval:BIB_20774
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network.
Journal
FEBS Letters
Author(s)
Le Goff X., Buvelot S., Salimova E., Guerry F., Schmidt S., Cueille N., Cano E., Simanis V.
ISSN
0014-5793
Publication state
Published
Issued date
2001
Volume
508
Number
1
Pages
136-142
Language
english
Notes
Publication types: Journal Article
Abstract
In order to identify regulators of the Schizosaccharomyces pombe septation initiation network (SIN), which signals the onset of cell division, we have isolated extragenic suppressors of mutations in the GTPase spg1p, which is a central element in this pathway. One of these encodes the protein phosphatase 2A (PP2A) B'-regulatory subunit par1p. Loss of par1p function rescues mutants in cdc11, cdc7, and spg1, but no other SIN mutants. Our data suggest that PP2A-par1p acts as a negative regulator of SIN signalling.
Keywords
Cell Division/physiology, Cloning, Molecular, Fluorescent Dyes/metabolism, Fungal Proteins/genetics, Fungal Proteins/metabolism, Green Fluorescent Proteins, Luminescent Proteins/metabolism, Phosphoprotein Phosphatases/genetics, Phosphoprotein Phosphatases/metabolism, Poly(A)-Binding Proteins, Protein Phosphatase 2, RNA-Binding Proteins/genetics, RNA-Binding Proteins/metabolism, Recombinant Fusion Proteins/genetics, Recombinant Fusion Proteins/metabolism, Schizosaccharomyces/cytology, Schizosaccharomyces/enzymology, Signal Transduction/physiology, Temperature
Pubmed
Web of science
Open Access
Yes
Create date
19/11/2007 12:15
Last modification date
20/08/2019 12:56
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