Detection limit, cut-off and specificity of an improved rapid assay for cardiac troponin T.
Details
Serval ID
serval:BIB_2073F6D8C45E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Detection limit, cut-off and specificity of an improved rapid assay for cardiac troponin T.
Journal
Clinical Laboratory
ISSN
1433-6510 (Print)
ISSN-L
1433-6510
Publication state
Published
Issued date
2001
Peer-reviewed
Oui
Volume
47
Number
11-12
Pages
549-554
Language
english
Notes
Publication types: Journal Article ; Multicenter Study Publication Status: ppublish
Abstract
The performance of an improved version of the troponin T rapid test TROPT Sensitive was investigated in a multicentre evaluation at twelve centres. The detection limit and the cut-off were determined in a method comparison with Elecsys Troponin T using a total of 365 samples from patients with suspected acute coronary syndromes and 91 samples from healthy blood donors or non-cardiological patients. The analytical specificity was determined by measuring 1271 blood samples from blood donors without any myocardial injury. The test cut-off (90% of results positive) is 0.08 microg/L, and the detection limit is about 0.05 microg/L. The analytical specificity of the test is between 99.7 and 99.9%. With its small area of undefined significance between positive and negative results and its high sensitivity and specificity, TROPT Sensitive is very well suited to the reliable detection of troponin T positive patients with acute coronary syndromes.
Keywords
Biological Markers/blood, Coronary Disease/blood, Coronary Disease/diagnosis, Humans, Myocardium/chemistry, Reagent Kits, Diagnostic/standards, Regression Analysis, Sensitivity and Specificity, Time Factors, Troponin T/blood
Pubmed
Create date
09/11/2014 16:46
Last modification date
20/08/2019 13:56