Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management.
Details
Serval ID
serval:BIB_2047695757D1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Abdominal pain in patients with inflammatory bowel disease: association with single-nucleotide polymorphisms prevalent in irritable bowel syndrome and clinical management.
Journal
BMC gastroenterology
Working group(s)
Swiss IBD Cohort Study Group
Contributor(s)
Anderegg C., Bauerfeind P., Beglinger C., Begré S., Belli D., Bengoa J.M., Biedermann L., Bigler B., Binek J., Blattmann M., Boehm S., Borovicka J., Braegger C.P., Brunner N., Bühr P., Burnand B., Burri E., Buyse S., Cremer M., Criblez D.H., de Saussure P., Degen L., Delarive J., Doerig C., Dora B., Dorta G., Egger M., Ehmann T., El-Wafa A., Engelmann M., Ezri J., Felley C., Fliegner M., Fournier N., Fraga M., Frei P., Frei R., Fried M., Froehlich F., Funk C., Furlano R.I., Gallot-Lavallée S., Geyer M., Girardin M., Golay D., Grandinetti T., Gysi B., Haack H., Haarer J., Helbling B., Hengstler P., Herzog D., Hess C., Heyland K., Hinterleitner T., Hiroz P., Hirschi C., Hruz P., Iwata R., Jost R., Juillerat P., Brondolo V.K., Knellwolf C., Knoblauch C., Köhler H., Koller R., Krieger-Grübel C., Kullak-Ublick G., Künzler P., Landolt M., Lange R., Lehmann F.S., Macpherson A., Maerten P., Maillard M.H., Manser C., Manz M., Marbet U., Marx G., Matter C., McLin V., Meier R., Mendanova M., Meyenberger C., Michetti P., Misselwitz B., Moradpour D., Morell B., Mosler P., Mottet C., Müller C., Müller P., Müllhaupt B., Münger-Beyeler C., Musso L., Nagy A., Neagu M., Nichita C., Niess J., Noël N., Nydegger A., Obialo N., Oneta C., Oropesa C., Peter U., Peternac D., Petit L.M., Piccoli-Gfeller F., Pilz J.B., Pittet V., Raschle N., Rentsch R., Restellini S., Richterich J.P., Rihs S., Ritz M.A., Roduit J., Rogler D., Rogler G., Rossel J.B., Sagmeister M., Saner G., Sauter B., Sawatzki M., Schäppi M., Scharl M., Schelling M., Schibli S., Schlauri H., Uebelhart S.S., Schnegg J.F., Schoepfer A., Seibold F., Seirafi M., Semadeni G.M., Semela D., Senning A., Sidler M., Sokollik C., Spalinger J., Spangenberger H., Stadler P., Steuerwald M., Straumann A., Straumann-Funk B., Sulz M., Thorens J., Tiedemann S., Tutuian R., Vavricka S., Viani F., Vögtlin J., Von Känel R., Vonlaufen A., Vouillamoz D., Vulliamy R., Wermuth J., Werner H., Wiesel P., Wiest R., Wylie T., Zeitz J., Zimmermann D.
ISSN
1471-230X (Electronic)
ISSN-L
1471-230X
Publication state
Published
Issued date
05/02/2021
Peer-reviewed
Oui
Volume
21
Number
1
Pages
53
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Abdominal pain is a frequent symptom in patients with inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC). Pain can result from ongoing inflammation or functional disorders imitating irritable bowel syndrome (IBS). Several single-nucleotide polymorphisms (SNPs) have been associated with IBS. However, the impact of IBS genetics on the clinical course of IBD, especially pain levels of patients remains unclear.
Data of 857 UC and 1206 CD patients from the Swiss IBD Cohort Study were analysed. We tested the association of the maximum of the abdominal pain item of disease activity indices in UC and CD over the study period with 16 IBS-associated SNPs, using multivariate ANOVA models.
In UC patients, the SNPs rs1042713 (located on the ADRB2 gene) and rs4663866 (close to the HES6 gene) were associated with higher abdominal pain levels (P = 0.044; P = 0.037, respectively). Abdominal pain was not associated with any markers of patient management in a model adjusted for confounders. In CD patients, higher levels of abdominal pain correlated with the number of physician contacts (P < 10 <sup>-15</sup> ), examinations (P < 10 <sup>-12</sup> ), medical therapies (P = 0.023) and weeks of hospitalisation (P = 0.0013) in a multivariate model.
We detected an association between maximal abdominal pain in UC patients and two IBS-associated SNPs. Abdominal pain levels had a pronounced impact on diagnostic and therapeutic procedures in CD but not in UC patients.
Data of 857 UC and 1206 CD patients from the Swiss IBD Cohort Study were analysed. We tested the association of the maximum of the abdominal pain item of disease activity indices in UC and CD over the study period with 16 IBS-associated SNPs, using multivariate ANOVA models.
In UC patients, the SNPs rs1042713 (located on the ADRB2 gene) and rs4663866 (close to the HES6 gene) were associated with higher abdominal pain levels (P = 0.044; P = 0.037, respectively). Abdominal pain was not associated with any markers of patient management in a model adjusted for confounders. In CD patients, higher levels of abdominal pain correlated with the number of physician contacts (P < 10 <sup>-15</sup> ), examinations (P < 10 <sup>-12</sup> ), medical therapies (P = 0.023) and weeks of hospitalisation (P = 0.0013) in a multivariate model.
We detected an association between maximal abdominal pain in UC patients and two IBS-associated SNPs. Abdominal pain levels had a pronounced impact on diagnostic and therapeutic procedures in CD but not in UC patients.
Keywords
Abdominal Pain/genetics, Cohort Studies, Colitis, Ulcerative/complications, Colitis, Ulcerative/genetics, Humans, Inflammatory Bowel Diseases/complications, Inflammatory Bowel Diseases/genetics, Irritable Bowel Syndrome/complications, Irritable Bowel Syndrome/genetics, Nucleotides, Polymorphism, Single Nucleotide, Abdominal pain, Crohn’s disease, Inflammatory bowel disease, Irritable bowel syndrome, Single-nucleotide polymorphisms, Ulcerative colitis
Pubmed
Web of science
Open Access
Yes
Create date
20/07/2021 11:28
Last modification date
12/01/2022 8:08
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