Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster.

Détails

ID Serval
serval:BIB_1FEFE287CD2B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster.
Périodique
Molecular biology and evolution
Auteur(s)
Kapun M., Fabian D.K., Goudet J., Flatt T.
ISSN
1537-1719 (Electronic)
ISSN-L
0737-4038
Statut éditorial
Publié
Date de publication
05/2016
Peer-reviewed
Oui
Volume
33
Numéro
5
Pages
1317-1336
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Clines in chromosomal inversion polymorphisms-presumably driven by climatic gradients-are common but there is surprisingly little evidence for selection acting on them. Here we address this long-standing issue in Drosophila melanogaster by using diagnostic single nucleotide polymorphism (SNP) markers to estimate inversion frequencies from 28 whole-genome Pool-seq samples collected from 10 populations along the North American east coast. Inversions In(3L)P, In(3R)Mo, and In(3R)Payne showed clear latitudinal clines, and for In(2L)t, In(2R)NS, and In(3R)Payne the steepness of the clinal slopes changed between summer and fall. Consistent with an effect of seasonality on inversion frequencies, we detected small but stable seasonal fluctuations of In(2R)NS and In(3R)Payne in a temperate Pennsylvanian population over 4 years. In support of spatially varying selection, we observed that the cline in In(3R)Payne has remained stable for >40 years and that the frequencies of In(2L)t and In(3R)Payne are strongly correlated with climatic factors that vary latitudinally, independent of population structure. To test whether these patterns are adaptive, we compared the amount of genetic differentiation of inversions versus neutral SNPs and found that the clines in In(2L)t and In(3R)Payne are maintained nonneutrally and independent of admixture. We also identified numerous clinal inversion-associated SNPs, many of which exhibit parallel differentiation along the Australian cline and reside in genes known to affect fitness-related traits. Together, our results provide strong evidence that inversion clines are maintained by spatially-and perhaps also temporally-varying selection. We interpret our data in light of current hypotheses about how inversions are established and maintained.

Mots-clé
Adaptation, Biological/genetics, Animals, Biological Evolution, Chromosome Inversion, Drosophila melanogaster/genetics, Evolution, Molecular, Genetics, Population/methods, Linkage Disequilibrium, Male, North America, Polymorphism, Single Nucleotide, Drosophila., chromosomal inversion polymorphisms, clinal adaptation, clines, population genomics, spatially and temporally varying selection
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/01/2016 12:11
Dernière modification de la notice
08/05/2019 15:33
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