Dormant and self-renewing hematopoietic stem cells and their niches.

Détails

ID Serval
serval:BIB_1FA10D47AD11
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Dormant and self-renewing hematopoietic stem cells and their niches.
Périodique
Annals of the New York Academy of Sciences
Auteur(s)
Wilson A., Oser G.M., Jaworski M., Blanco-Bose W.E., Laurenti E., Adolphe C., Essers M.A., Macdonald H.R., Trumpp A.
ISSN
0077-8923
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
1106
Pages
64-75
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
In the mouse, over the last 20 years, a set of cell-surface markers and activities have been identified, enabling the isolation of bone marrow (BM) populations highly enriched in hematopoietic stem cells (HSCs). These HSCs have the ability to generate multiple lineages and are capable of long-term self-renewal activity such that they are able to reconstitute and maintain a functional hematopoietic system after transplantation into lethally irradiated recipients. Using single-cell reconstitution assays, various marker combinations can be used to achieve a functional HSC purity of almost 50%. Here we have used the differential expression of six of these markers (Sca1, c-Kit, CD135, CD48, CD150, and CD34) on lineage-depleted BM to refine cell hierarchies within the HSC population. At the top of the hierarchy, we propose a dormant HSC population (Lin(-)Sca1(+)c-Kit(+) CD48(-)CD150(+)CD34(-)) that gives rise to an active self-renewing CD34(+) HSC population. HSC dormancy, as well as the balance between self-renewal and differentiation activity, is at least, in part, controlled by the stem cell niches individual HSCs are attached to. Here we review the current knowledge about HSC niches and propose that dormant HSCs are located in niches at the endosteum, whereas activated HSCs are in close contact to sinusoids of the BM microvasculature.
Mots-clé
Animals, Bone Marrow/metabolism, Bone Marrow Cells/cytology, Cell Differentiation, Gene Expression Regulation, Hematopoietic Stem Cells/cytology, Mice, Models, Biological, Models, Genetic, Osteoblasts/metabolism, Phenotype
Pubmed
Web of science
Création de la notice
09/02/2010 14:06
Dernière modification de la notice
20/08/2019 12:55
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