Neuroendocrine carcinomas of the breast.

Détails

ID Serval
serval:BIB_1F6CD017124F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neuroendocrine carcinomas of the breast.
Périodique
International Journal of Surgery (london, England)
Auteur(s)
Rovera F., Masciocchi P., Coglitore A., La Rosa S., Dionigi G., Marelli M., Boni L., Dionigi R.
ISSN
1743-9159 (Electronic)
ISSN-L
1743-9159
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
6
Numéro
Suppl 1
Pages
S113-S115
Langue
anglais
Notes
Publication types: Comparative Study ; Journal ArticlePublication Status: ppublish
Résumé
INTRODUCTION: Neuroendocrine (NE) breast cancers encompass a heterogeneous group of tumours showing morphological features similar to those of NE neoplasms of the gut and lung and expressing one or more neuroendocrine markers (neuron specific enolase, chromogranins synaptophysin) in at least 50% of tumour cells. They are rare lesions representing about 2-3% of all breast cancers and affecting more frequently elderly patients.
AIM: Prospective observational study is to analyse the clinico-pathological aspects of NE carcinomas of the breast undergone surgical resection compared to breast carcinomas with a minor neuroendocrine component and to conventional invasive ductal or lobular cancers.
MATERIAL AND METHOD: Thirty-five consecutive breast carcinomas showing morphological features suggestive of an endocrine differentiation were selected among breast cancers undergone surgical treatment during the period of January 1979-December 2004.
RESULTS: The 35 patients were divided into two categories: 13 neuroendocrine carcinomas (NECs) and 22 ductal carcinomas with a minor neuroendocrine component (DC-NE). The average follow-up was 60 months. The patients with CNE developed breast cancer in an advanced age compared to the patients with infiltrating ductal carcinoma NAS or infiltrating lobular carcinoma. We did not find recurrent disease in the NEC group, while it was observed in 2 patients (9%) with DC-NE, in 6 cases (17%) with infiltrating ductal carcinoma NAS and in 7 cases (20%) with infiltrating lobular carcinoma.
DISCUSSION: The CNE compared with the infiltrating ductal and lobular carcinoma are statistically different in relation to the expression of the receptor of c-erb-B2, p53, progesterone, for the lymph node state at diagnosis and the risk of reappearance of breast tumour. Our study confirms the choice to consider the neuroendocrine carcinoma of the breast as a separate histological group and seems to suggest a less aggressiveness of this type of tumour.
Mots-clé
Aged, Aged, 80 and over, Antigens, CD56/biosynthesis, Biomarkers, Tumor/biosynthesis, Breast Neoplasms/diagnosis, Breast Neoplasms/metabolism, Carcinoma, Neuroendocrine/diagnosis, Carcinoma, Neuroendocrine/metabolism, Chromogranin A/biosynthesis, Diagnosis, Differential, Female, Follow-Up Studies, Humans, Immunohistochemistry, Mastectomy/methods, Middle Aged, Neoplasm Staging/methods, Phosphopyruvate Hydratase/biosynthesis, Prognosis, Prospective Studies, Receptors, Estrogen/biosynthesis, Receptors, Progesterone/biosynthesis, Synaptophysin/biosynthesis, Time Factors
Pubmed
Open Access
Oui
Création de la notice
06/09/2016 14:02
Dernière modification de la notice
20/08/2019 12:55
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