Nimesulide, a cyclooxygenase-2 preferential inhibitor, impairs renal function in the newborn rabbit.

Détails

ID Serval
serval:BIB_1F5F606408E8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Nimesulide, a cyclooxygenase-2 preferential inhibitor, impairs renal function in the newborn rabbit.
Périodique
Pediatric Research
Auteur(s)
Prévot A., Mosig D., Martini S., Guignard J.P.
ISSN
0031-3998
Statut éditorial
Publié
Date de publication
2004
Peer-reviewed
Oui
Volume
55
Numéro
2
Pages
254-260
Langue
anglais
Résumé
Tocolysis with nonsteroidal anti-inflammatory drugs (NSAIDs) has been widely accepted for several years. Recently, the use of the cyclooxygenase-2 (COX2) preferential NSAID nimesulide has been proposed. However, data reporting neonatal acute renal failure or irreversible end-stage renal failure after maternal ingestion of nimesulide question the safety of this drug for the fetus and the neonate. Therefore, this study was designed to define the renal effects of nimesulide in newborn rabbits. Experiments were performed in 28 newborn rabbits. Renal function and hemodynamic parameters were measured using inulin and para-aminohippuric acid clearances as markers of GFR and renal blood flow, respectively. After a control period, nimesulide 2, 20, or 200 microg/kg was given as an i.v. bolus, followed by a 0.05, 0.5, or 5 microg.kg(-1).min(-1) infusion. Nimesulide administration induced a significant dose-dependent increase in renal vascular resistance (29, 37, and 92%, respectively), with a concomitant decrease in diuresis (-5, -23, and -44%), GFR (-12, -23, and -47%), and renal blood flow (-23, -23, and -48%). These results are in contrast with recent reports claiming that selective COX2 inhibition could be safer for the kidney than nonselective NSAIDs. These experiments confirm that prostaglandins, by maintaining renal vasodilation, play a key role in the delicate balance regulating neonatal GFR. We conclude that COX2-selective/preferential inhibitors thus should be prescribed with the same caution as nonselective NSAIDs during pregnancy and in the neonatal period.
Mots-clé
Animals, Animals, Newborn, Blood Pressure/drug effects, Cyclooxygenase 2, Cyclooxygenase 2 Inhibitors, Cyclooxygenase Inhibitors/pharmacology, Glomerular Filtration Rate/drug effects, Injections, Intravenous, Isoenzymes/antagonists & inhibitors, Kidney/drug effects, Kidney/growth & development, Prostaglandin-Endoperoxide Synthases, Rabbits, Sulfonamides/pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/07/2009 14:10
Dernière modification de la notice
08/05/2019 15:30
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