Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.

Détails

ID Serval
serval:BIB_1ECFC1603DDF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Autocrine Action of IGF2 Regulates Adult β-Cell Mass and Function.
Périodique
Diabetes
Auteur(s)
Modi H., Jacovetti C., Tarussio D., Metref S., Madsen O.D., Zhang F.P., Rantakari P., Poutanen M., Nef S., Gorman T., Regazzi R., Thorens B.
ISSN
1939-327X (Electronic)
ISSN-L
0012-1797
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
64
Numéro
12
Pages
4148-4157
Langue
anglais
Résumé
Insulin-like growth factor 2 (IGF2), produced and secreted by adult β-cells, functions as an autocrine activator of the β-cell insulin-like growth factor 1 receptor signaling pathway. Whether this autocrine activity of IGF2 plays a physiological role in β-cell and whole-body physiology is not known. Here, we studied mice with β-cell-specific inactivation of Igf2 (βIGF2KO mice) and assessed β-cell mass and function in aging, pregnancy, and acute induction of insulin resistance. We showed that glucose-stimulated insulin secretion (GSIS) was markedly reduced in old female βIGF2KO mice; glucose tolerance was, however, normal because of increased insulin sensitivity. While on a high-fat diet, both male and female βIGF2KO mice displayed lower GSIS compared with control mice, but reduced β-cell mass was observed only in female βIGF2KO mice. During pregnancy, there was no increase in β-cell proliferation and mass in βIGF2KO mice. Finally, β-cell mass expansion in response to acute induction of insulin resistance was lower in βIGF2KO mice than in control mice. Thus, the autocrine action of IGF2 regulates adult β-cell mass and function to preserve in vivo GSIS in aging and to adapt β-cell mass in response to metabolic stress, pregnancy hormones, and acute induction of insulin resistance.
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/12/2015 13:08
Dernière modification de la notice
20/08/2019 12:54
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