IL-6 production in response to purified mycobacterial heat-shock proteins and to antigen 85 in leprosy.

Details

Serval ID
serval:BIB_1EB9B859EC1F
Type
Article: article from journal or magazin.
Collection
Publications
Title
IL-6 production in response to purified mycobacterial heat-shock proteins and to antigen 85 in leprosy.
Journal
Cellular Immunology
Author(s)
Launois P., Vandenbussche P., M'Bayame N.N., Drowart A., Van Vooren J.P., Sarthou J.L., Millan J., Huygen K.
ISSN
0008-8749 (Print)
ISSN-L
0008-8749
Publication state
Published
Issued date
1993
Volume
148
Number
2
Pages
283-290
Language
english
Abstract
IL-6 production was examined in PBMC cultures from healthy leprosy contacts and from leprosy patients stimulated with the purified mycobacterial 18-, 65-, and 70-kDa heat-shock proteins (hsp) and the secreted fibronectin-binding antigen 85 (Ag85). In lepromin-negative contacts, the 70-kDa hsp was the only antigen capable of eliciting significant IL-6 production. In lepromin-positive contacts, Ag85, the 65- and the 70-kDa hsp induced substantial IL-6 titers. IL-6 levels induced with the 70-kDa antigen were about fourfold higher than with the 65-kDa hsp or with Ag85. The 18-kDa antigen did not induce any IL-6 in these healthy contacts. PBMC from tuberculoid leprosy patients produced even more elevated levels of IL-6, and PBMC from lepromatous leprosy patients produced extremely high levels of IL-6. All antigens were capable of inducing IL-6 in leprosy patients. Highest levels were found in cultures stimulated with the 65-kDa hsp, and lowest levels were in cultures stimulated with the 18-kDa hsp.
Keywords
Antigens, Bacterial/immunology, Cells, Cultured, Heat-Shock Proteins/immunology, Humans, Interleukin-6/biosynthesis, Lepromin/analysis, Leprosy, Lepromatous/immunology, Leprosy, Tuberculoid/immunology, Mycobacterium/immunology
Pubmed
Web of science
Create date
28/01/2008 11:06
Last modification date
20/08/2019 12:54
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