Drug uptake in a rodent sarcoma model after intravenous injection or isolated lung perfusion of free/liposomal doxorubicin.

Détails

ID Serval
serval:BIB_1E63104FAB1A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Drug uptake in a rodent sarcoma model after intravenous injection or isolated lung perfusion of free/liposomal doxorubicin.
Périodique
Interactive Cardiovascular and Thoracic Surgery
Auteur(s)
Cheng C., Haouala A., Krueger T., Mithieux F., Perentes J.Y., Peters S., Decosterd L.A., Ris H.B.
ISSN
1569-9285 (Electronic)
ISSN-L
1569-9285
Statut éditorial
Publié
Date de publication
2009
Volume
8
Numéro
6
Pages
635-638
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The distribution of free and liposomal doxorubicin (Liporubicin) administered by intravenous injection (IV) or isolated lung perfusion (ILP) was compared in normal and tumor tissues of sarcoma bearing rodent lungs. A single sarcomatous tumor was generated in the left lung of 35 Fischer rats, followed 10 days later by left-sided ILP (n=20) or IV drug administration (n=12), using 100 microg and 400 microg free or liposomal doxorubicin, respectively. The tumor and lung tissue drug concentration was measured by HPLC. Free doxorubicin administered by ILP resulted in a three-fold (100 microg) and 10-fold (400 microg) increase of the drug concentration in the tumor and normal lung tissue compared to IV administration. In contrast, ILP with Liporubicin resulted in a similar drug uptake in the tumor and lung tissue compared to IV injection. For both drug formulations and dosages, ILP resulted in a higher tumor to lung tissue drug ratio but also in a higher spatial heterogeneity of drug distribution within the lung compared to IV administration. ILP resulted in a higher tumor to lung tissue drug ratio and in a more heterogeneous drug distribution within the lung compared to IV drug administration.
Mots-clé
Animals, Antibiotics, Antineoplastic/administration & dosage, Antibiotics, Antineoplastic/metabolism, Biological Transport, Cell Line, Tumor, Chemistry, Pharmaceutical, Doxorubicin/administration & dosage, Doxorubicin/metabolism, Injections, Intravenous, Liposomes, Lung Neoplasms/metabolism, Male, Perfusion, Rats, Rats, Inbred F344, Sarcoma/metabolism, Tissue Distribution
Pubmed
Open Access
Oui
Création de la notice
03/09/2009 8:11
Dernière modification de la notice
20/08/2019 13:54
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