Colonic carcinoma with a pancreatic acinar cell differentiation. A case report.

Détails

ID Serval
serval:BIB_1E5EEF7D63F7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Colonic carcinoma with a pancreatic acinar cell differentiation. A case report.
Périodique
Virchows Archiv : An International Journal of Pathology
Auteur(s)
Chiaravalli A.M., Finzi G., Bertolini V., La Rosa S., Capella C.
ISSN
1432-2307 (Electronic)
ISSN-L
0945-6317
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
455
Numéro
6
Pages
527-531
Langue
anglais
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Résumé
A case of a colonic carcinoma showing a pancreatic acinar cell differentiation is described for the first time. A 65-year-old woman underwent surgical resection for an ulcerated protruding tumour of 4 x 2.5 cm in size on the anterior wall of the sigmoid colon. Histologically, tumour cells were organized in acinar structures resembling pancreatic acini and in solid nests and ribbons or diffusely infiltrated as poorly cohesive cells. Lymph nodes and femur metastases displayed the same histological features. The ultrastructural analysis of the primary tumour indicated the presence of zymogen-like granules in the cytoplasm of tumour cells. Immunohistochemically, both acinar and diffuse patterns of growth showed an intense staining for trypsin, chymotrypsin and BCL10 and a weaker immunoreactivity for lipase and carboxyl ester hydrolase. Most tumour cells were cytokeratin 20, CDX2 and p53 positive; whereas, mucin (MUC)2 immunoreactivity was observed only in the signet ring cells present in the diffuse pattern and chromogranin A in rare isolated tumour cells. No immunoreactivity was observed for cytokeratin 7, MUC1, MUC5AC, pancreatic amylase or PDX1. There was no evidence of a pancreatic acinar cell carcinoma or of heterotopic pancreatic tissue. A colonic origin ought to be suspected when a metastatic carcinoma of unknown primary shows an acinar differentiation.
Mots-clé
Aged, Carcinoma, Acinar Cell/pathology, Cell Differentiation, Colonic Neoplasms/pathology, Fatal Outcome, Female, Homeodomain Proteins/metabolism, Humans, Immunohistochemistry, Keratin-20/metabolism, Lymphatic Metastasis, Pancreatic Neoplasms/pathology, Tumor Suppressor Protein p53/metabolism
Pubmed
Web of science
Création de la notice
06/09/2016 13:56
Dernière modification de la notice
20/08/2019 12:54
Données d'usage