Plectin, an unusual target antigen in bullous pemphigoid
Details
Serval ID
serval:BIB_1DB36D96EAC6
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Plectin, an unusual target antigen in bullous pemphigoid
Journal
British Journal of Dermatology
ISSN
0007-0963 (Print)
Publication state
Published
Issued date
01/2001
Volume
144
Number
1
Pages
136-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
BACKGROUND: Bullous pemphigoid (BP) is a blistering disease associated with autoantibodies directed against two components of hemidesmosomes, BP180 and BP230. OBJECTIVES: To assess whether BP patients have autoantibodies targeting plectin, another hemidesmosomal component showing extensive homology to BP230. METHODS: Examination of sera from 16 patients with BP, using immunoprecipitation studies followed by immunoblotting. RESULTS: Serum of one of the 16 (6%) patients with BP contain autoantibodies binding to plectin, while no reactivity was found with sera from three control subjects. Sera from all 16 BP patients immunoprecipitated BP230 from extracts of biosynthetically radiolabelled human keratinocytes. CONCLUSIONS: Our results indicate that sera from BP patients might contain autoantibodies binding to plectin. Although this protein and BP230 are closely sequence-related, the occurrence of autoantibodies binding to plectin is a rare phenomenon in BP.
Keywords
Autoantibodies/blood
Autoantigens/*immunology
Autoimmune Diseases/*immunology
*Carrier Proteins
Collagen/immunology
*Cytoskeletal Proteins
Humans
Immunoblotting
Intermediate Filament Proteins/*immunology
*Nerve Tissue Proteins
*Non-Fibrillar Collagens
Pemphigoid, Bullous/*immunology
Plectin
Radioimmunoprecipitation Assay
Pubmed
Web of science
Create date
25/01/2008 16:41
Last modification date
20/08/2019 12:54