E2F1, a Novel Regulator of Metabolism.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_1D63D7156464
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
E2F1, a Novel Regulator of Metabolism.
Périodique
Frontiers in endocrinology
Auteur(s)
Denechaud P.D., Fajas L., Giralt A.
ISSN
1664-2392 (Print)
ISSN-L
1664-2392
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
8
Pages
311
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
In the past years, several lines of evidence have shown that cell cycle regulatory proteins also can modulate metabolic processes. The transcription factor E2F1 is a central player involved in cell cycle progression, DNA-damage response, and apoptosis. Its crucial role in the control of cell fate has been extensively studied and reviewed before; however, here, we focus on the participation of E2F1 in the regulation of metabolism. We summarize recent findings about the cell cycle-independent roles of E2F1 in various tissues that contribute to global metabolic homeostasis and highlight that E2F1 activity is increased during obesity. Finally, coming back to the pivotal role of E2F1 in cancer development, we discuss how E2F1 links cell cycle progression with different metabolic adaptations required for cell growth and survival.

Mots-clé
E2F1, cancer metabolism, cell cycle regulators, metabolic diseases, obesity
Pubmed
Web of science
Open Access
Oui
Création de la notice
30/11/2017 19:54
Dernière modification de la notice
08/05/2019 15:23
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