Article: article from journal or magazin.
Prognostic factors influencing survival from metastatic (stage IV) gastroenteropancreatic well-differentiated endocrine carcinoma
Endocr Relat Cancer
1351-0088 (Print)1351-0088 (Linking)
Durante, CosimoBoukheris, HoudaDromain, ClarisseDuvillard, PierreLeboulleux, SophieElias, Dominiquede Baere, ThierryMalka, DavidLumbroso, JeanGuigay, JoelSchlumberger, MartinDucreux, MichelBaudin, EricengIntramural NIH HHS/Clinical TrialResearch Support, N.I.H., ExtramuralResearch Support, N.I.H., IntramuralEngland2009/02/26 09:00Endocr Relat Cancer. 2009 Jun;16(2):585-97. doi: 10.1677/ERC-08-0301. Epub 2009 Feb 24.
Survival of metastatic gastroenteropancreatic well-differentiated endocrine carcinoma (GEP WDEC) is not well characterized. We evaluated the long-term outcome and prognostic factors for survival in 118 patients with distant metastases from GEP WDEC. Inclusion criteria were 1) pathological review by a single pathologist according to the present WHO criteria, 2) absence of previous therapy apart from surgery, 3) complete morphological evaluation within 3 months including somatostatin receptor scintigraphy, and 4) follow-up at Gustave-Roussy Institute until death or study's end. Clinical, biological marker, and pathological parameters were analyzed in univariate and multivariate statistical models. Survival after the first complete imaging work-up of the metastatic disease was determined using Kaplan-Meier method. Overall, survival for 5 years after the diagnosis of metastatic disease was 54%. In multivariate analysis, age (hazard ratio (HR): 1.05, 95% confidence interval (CI): 1.01-1.08, P = 0.01), the number of liver metastases (HR: 3.4, 95% CI: 1.4-8.3, P = 0.01), tumor slope (HR: 1.1, 95% CI: 1.0-1.1, P = 0.001), and initial surgery (HR: 0.3, 95% CI: 0.1-0.8, P = 0.01) were predictive of survival. Five-year survival was 100%, 91% (95% CI, 51-98%), 62% (95% CI, 37-83%), and 9% (95% CI, 6-32%) when patients had 0, 1, 2, 3 or more poor prognostic features respectively. This study enables the stratification of metastatic GEP WDEC patients into distinct risk groups. These risk categories can be used to tailor therapeutic approaches and also to design and interpret clinical trials.
Adolescent, Adult, Aged, Aged, 80 and over, *Cell Differentiation, Child, Female, Gastrointestinal Neoplasms/*mortality/secondary, Humans, Male, Middle Aged, Neoplasm Staging, Neuroendocrine Tumors/*mortality/pathology, Pancreatic Neoplasms/*mortality/secondary, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, Young Adult
Last modification date