Mls-1 and Mls-2 superantigens do not control susceptibility to collagen-induced arthritis in HI and HII mice

Détails

ID Serval
serval:BIB_1CE5CE7A1CB6
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Mls-1 and Mls-2 superantigens do not control susceptibility to collagen-induced arthritis in HI and HII mice
Périodique
Immunology
Auteur(s)
Roger  T., Boudaly  S., Couderc  J., Seman  M.
ISSN
0019-2805 (Print)
Statut éditorial
Publié
Date de publication
12/1993
Volume
80
Numéro
4
Pages
661-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
The HI mouse line is sensitive to collagen-induced arthritis (CIA), whereas HII is refractory, although both express the H-2q permissive haplotype. The two lines also share the same T-cell receptor (TcR) gene haplotypes for alpha and beta chains. The distribution of mouse mammary tumour viruses (MMTV), which encode endogenous superantigens (SAg) such as minor leucocyte-stimulating antigens (Mls) known to modulate the available TcR-V beta repertoire, was investigated in the two lines. Mls-1 is present in HI-susceptible mice, while Mls-2 and Mls-2-like SAg are absent in both lines. This suggests that Mls antigens play no significant role in the resistance to CIA. Moreover, HI and HII exhibit close V beta gene usage as assessed by fluorescence staining with 11 V beta-specific monoclonal antibodies (mAb). These results indicate that mechanisms other than clonal deletion based on V beta expression and induced by SAg are involved in the resistance of H-2q-positive mice to experimental arthritis. Yet, a slightly reduced level of V beta 5+ T cells is observed in HII animals which might correlate with the presence of Mtv-6 and Mtv-9 proviruses.
Mots-clé
Animals Arthritis/*immunology Autoimmune Diseases/*immunology Blotting, Southern Collagen/*immunology Disease Susceptibility Humans Mammary Tumor Virus, Mouse/isolation & purification Mice Mice, Inbred Strains Minor Lymphocyte Stimulatory Antigens/*analysis Superantigens/*immunology
Pubmed
Web of science
Création de la notice
25/01/2008 14:35
Dernière modification de la notice
03/03/2018 14:33
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