Evolutionary Convergence and Divergence in NLR Function and Structure.

Détails

ID Serval
serval:BIB_1CDD0C7777E0
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Evolutionary Convergence and Divergence in NLR Function and Structure.
Périodique
Trends in immunology
Auteur(s)
Meunier E., Broz P.
ISSN
1471-4981 (Electronic)
ISSN-L
1471-4906
Statut éditorial
Publié
Date de publication
10/2017
Peer-reviewed
Oui
Volume
38
Numéro
10
Pages
744-757
Langue
anglais
Résumé
The recognition of cellular damage caused by either pathogens or abiotic stress is essential for host defense in all forms of life in the plant and animal kingdoms. The NOD-like receptors (NLRs) represent a large family of multidomain proteins that were initially discovered for their role in host defense in plants and vertebrates. Over recent years the wide distribution of NLRs among metazoans has become apparent and their origins have begun to emerge. Moreover, intense study of NLR function has shown that they play essential roles beyond pathogen recognition - in the regulation of antigen presentation, cell death, inflammation, and even in embryonic development. We summarize here the latest insights into NLR biology and discuss examples of converging and diverging evolution of NLR function and structure.

Pubmed
Web of science
Création de la notice
25/10/2017 11:05
Dernière modification de la notice
20/08/2019 13:53
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