Induction of specific immune unresponsiveness using purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. I. Demonstration of general validity as to species and histocompatibility barriers.

Détails

ID Serval
serval:BIB_1CD24DE6041D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Induction of specific immune unresponsiveness using purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. I. Demonstration of general validity as to species and histocompatibility barriers.
Périodique
Journal of Experimental Medicine
Auteur(s)
Andersson L.C., Aguet M., Wight E., Andersson R., Binz H., Wigzell H.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
1977
Volume
146
Numéro
4
Pages
1124-1137
Langue
anglais
Résumé
Normal immunocompetent T lymphocytes can be induced into specific proliferation if confronted with the relevant alloantigen in vitro. Such mixed leuko-cyteculture-activated T lymphoblasts carring idiotypic receptors on their surface can be purified using velocity sedimentation and serve as immunogen if administered in adjuvant to the autologous host. Autoblast immunization can be shown to lead to specific, long-lasting unresponsiveness against the relevant alloantigens, while leaving reactivity against third-party antigens intact. When tested as to general validity, it could be shown to function in all species analyzed (mouse, rat, and guinea pig) as well as across both major and minor histocompatibility barriers. No negative side effects have been noted so far. It would thus seem clear that autoblast immunization using the above described scheme may serve as a general tool in inducing long-lasting, specific unresponsiveness in any species and across any histocompatibility barrier.
Mots-clé
Animals, Antigens, Autoantigens, Cell Separation/methods, Cytotoxicity Tests, Immunologic, Dose-Response Relationship, Immunologic, Genes, Guinea Pigs, Histocompatibility Antigens, Immune Tolerance, Immunity, Cellular, Immunoglobulin Allotypes, Isoantigens, Kinetics, Lymphocyte Activation, Mice, Rats, Species Specificity, T-Lymphocytes/immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:37
Dernière modification de la notice
08/05/2019 15:21
Données d'usage