Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release.

Détails

Ressource 1Télécharger: BIB_1CCBCA503F06.P001.pdf (219.59 [Ko])
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_1CCBCA503F06
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release.
Périodique
Obesity
Auteur(s)
Rodieux F., Giusti V., D'Alessio D.A., Suter M., Tappy L.
ISSN
1930-7381 (Print)
ISSN-L
1930-7381
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
16
Numéro
2
Pages
298-305
Langue
anglais
Résumé
BACKGROUND: Bariatric surgery markedly improves glucose homeostasis in patients with type 2 diabetes even before any significant weight loss is achieved. Procedures that involve bypassing the proximal small bowel, such as Roux-en-Y gastric bypass (RYGBP), are more efficient than gastric restriction procedures such as gastric banding (GB).
OBJECTIVE: To evaluate the effects of RYGBP and GB on postprandial glucose kinetics and gastro-intestinal hormone secretion after an oral glucose load.
METHODS AND PROCEDURES: This study was a cross-sectional comparison among non-diabetic, weight-stable women who had undergone RYGBP (n = 8) between 9 and 48 months earlier or GB (n = 6) from 25 to 85 months earlier, and weight- and age-matched control subjects (n = 8). The women were studied over 4 h following ingestion of an oral glucose load. Total glucose and meal glucose kinetics were assessed using glucose tracers and plasma insulin, and gut hormone concentrations were simultaneously monitored.
RESULTS: Patients who had undergone RYGBP showed a a more rapid appearance of exogenous glucose in the systemic circulation and a shorter duration of postprandial hyperglycemia than patients who had undergone GB and C. The response in RYGBP patients was characterized by early and accentuated insulin response, enhanced postprandial levels of glucagon-like peptide-1 (GLP-1) and polypeptide YY (PYY), and greater postprandial suppression of ghrelin.
DISCUSSION: These findings indicate that RYGBP is associated with alterations in glucose kinetics and glucoregulatory hormone secretion. These alterations are probably secondary to the anatomic rearrangement of the foregut, given the fact that they are not observed after GB. Increased PYY and GLP-1 concentrations and enhanced ghrelin suppression are compatible with reduced food intake after RYGBP.
Mots-clé
Adolescent, Adult, Bariatric Surgery, Blood Glucose/metabolism, Case-Control Studies, Cross-Sectional Studies, Eating/physiology, Fatty Acids, Nonesterified/blood, Female, Gastric Bypass, Gastrointestinal Hormones/metabolism, Ghrelin/blood, Glucagon-Like Peptide 1/blood, Glucose/metabolism, Homeostasis/physiology, Humans, Insulin/blood, Middle Aged, Peptide YY/blood
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/10/2008 9:04
Dernière modification de la notice
08/05/2019 15:21
Données d'usage