Cancer incidence among capacitor manufacturing workers exposed to polychlorinated biphenyls

Détails

Ressource 1Télécharger: 2017_Ruder_Post-print_Text.pdf (568.79 [Ko])
Etat: Serval
Version: Author's accepted manuscript
ID Serval
serval:BIB_1CBFC1F6EE48
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cancer incidence among capacitor manufacturing workers exposed to polychlorinated biphenyls
Périodique
American Journal of Industrial Medicine
Auteur(s)
Ruder Avima M., Hein Misty J., Hopf Nancy B., Waters Martha A.
ISSN
1097-0274 (Electronic)
ISSN-L
0271-3586
Statut éditorial
Publié
Date de publication
02/2017
Peer-reviewed
Oui
Volume
60
Numéro
2
Pages
198-207
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
We evaluated cancer incidence in a cohort of polychlorinated biphenyl (PCB) exposed workers.
Incident cancers, identified using state registries, were compared to those in a national population using standardized incidence ratios. Trends in prostate cancer incidence with cumulative PCB exposure were evaluated using standardized rate ratios and Cox regression models. For selected sites, cumulative PCB exposure was compared between aggressive (fatal/distant stage) and localized/regional cancers.
We identified 3,371 invasive first primary cancer diagnoses among 21,317 eligible workers through 2007. Overall relative incidence was reduced. Elevations were only observed for respiratory cancers and among women, urinary organ cancers. Among men, prostate cancer incidence was reduced and not associated with cumulative PCB exposure although median exposures were significantly higher for aggressive compared to localized/regional prostate cancers.
Previously observed associations between cumulative PCB exposure and prostate cancer mortality were not confirmed in this analysis; prostate cancer stage at diagnosis may explain the discrepancy. Am. J. Ind. Med. 60:198-207, 2017. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

Mots-clé
Neoplasms, Polychlorinated Biphenyls, Occupational Exposure
Pubmed
Web of science
Création de la notice
18/01/2017 19:28
Dernière modification de la notice
03/03/2018 14:32
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