Induction of calmodulin kinase IV by the thyroid hormone during the development of rat brain.

Détails

ID Serval
serval:BIB_1CB140F84364
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Induction of calmodulin kinase IV by the thyroid hormone during the development of rat brain.
Périodique
Journal of Biological Chemistry
Auteur(s)
Krebs J., Means R.L., Honegger P.
ISSN
0021-9258 (Print)
ISSN-L
0021-9258
Statut éditorial
Publié
Date de publication
1996
Volume
271
Numéro
19
Pages
11055-11058
Langue
anglais
Résumé
This communication reports the specific induction of calmodulin kinase IV by the thyroid hormone 3,3',5-triiodo-L-thyronine (T3) in a time- and concentration-dependent manner at a very early stage of brain differentiation using a fetal rat telencephalon primary cell culture system, which can grow and differentiate under chemically defined conditions. The induction of the enzyme that can be observed both on the mRNA and on the protein level is T3-specific, i.e. it cannot be induced by retinoic acid or reverse T3, and can be inhibited on both the transcriptional and the translational level by adding to the culture medium actinomycin D or cycloheximide, respectively. The earliest detection of calmodulin kinase IV in the fetal brain tissue of the rat is at days E16/E17, both on the mRNA as well as on the protein level. This is the first report in which a second messenger-dependent kinase involved in the control of cell regulatory processes is itself controlled by a primary messenger, the thyroid hormone.
Mots-clé
Animals, Calcium-Calmodulin-Dependent Protein Kinase Type 4, Calcium-Calmodulin-Dependent Protein Kinases/biosynthesis, Calcium-Calmodulin-Dependent Protein Kinases/isolation & purification, Calmodulin/metabolism, Cells, Cultured, Enzyme Induction, Fetus, Gene Expression Regulation, Enzymologic/drug effects, Neurons/enzymology, RNA, Messenger/biosynthesis, Rats, Rats, Inbred Strains, Telencephalon/enzymology, Triiodothyronine/pharmacology
Pubmed
Web of science
Création de la notice
24/01/2008 14:12
Dernière modification de la notice
03/03/2018 14:32
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