Plasma norepinephrine kinetics, dopamine-beta-hydroxylase, and chromogranin-A, in hypothyroid patients before and following replacement therapy

Détails

ID Serval
serval:BIB_1CAEAD36E07D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Plasma norepinephrine kinetics, dopamine-beta-hydroxylase, and chromogranin-A, in hypothyroid patients before and following replacement therapy
Périodique
Journal of Clinical Endocrinology and Metabolism
Auteur(s)
Polikar  R., Kennedy  B., Ziegler  M., O'Connor  D. T., Smith  J., Nicod  P.
ISSN
0021-972X (Print)
Statut éditorial
Publié
Date de publication
01/1990
Volume
70
Numéro
1
Pages
277-81
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jan
Résumé
Whether the increased plasma norepinephrine level reported in hypothyroidism is the result of impaired norepinephrine (NE) clearance or increased NE release by nerve terminals is unknown. We, therefore, measured plasma NE levels and clearance in 11 hypothyroid patients before [T4 index, 41.2 +/- 7.7 nmol/L (mean +/- SEM); TSH, 71.4 +/- 23.0 mU/L] and 4 +/- 0.5 months after thyroid replacement (T4 index, 136.4 +/- 24.4 nmol/L; TSH, 3.2 +/- 1.2 mU/L) and in 8 healthy volunteers. Plasma dopamine-beta-hydroxylase and chromogranin-A, which are coreleased with NE by sympathetic nerve endings, were also measured. Plasma NE was higher in the hypothyroid (2.37 +/- 0.24 nmol/L) than in the euthyroid state (1.86 +/- 0.24 nmol/L; P less than 0.02) or in the controls (1.87 +/- 0.27 nmol/L). Plasma clearance of NE, however, was not affected after thyroid replacement (hypothyroid, 2.08 +/- 0.31 L/min; euthyroid, 1.94 +/- 0.21 L/min; controls, 1.86 +/- 0.15 L/min). There was no significant change in plasma dopamine-beta-hydroxylase (hypothyroid, 720 +/- 139 nmol/mL.h; euthyroid, 553 +/- 97 nmol/mL.h) or plasma chromogranin-A (hypothyroid, 48.9 +/- 7.1 ng/mL; euthyroid, 42.9 +/- 5.3 ng/mL) after thyroid replacement. We conclude that the increased plasma NE in hypothyroid patients is not due to a change in plasma clearance, but is more likely secondary to increased NE release.
Mots-clé
Adult Aged Chromogranin A Chromogranins/*blood Dopamine beta-Hydroxylase/*blood Female Half-Life Humans Hypothyroidism/blood/*drug therapy Male Metabolic Clearance Rate Middle Aged Nerve Endings/enzymology Nerve Tissue Proteins/*blood Norepinephrine/*pharmacokinetics Thyrotropin/blood Thyroxine/*therapeutic use
Pubmed
Web of science
Création de la notice
25/01/2008 15:00
Dernière modification de la notice
03/03/2018 14:32
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