Neural synchrony indexes impaired motor slowing after errors and novelty following white matter damage.

Détails

ID Serval
serval:BIB_1C942494CFC9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Neural synchrony indexes impaired motor slowing after errors and novelty following white matter damage.
Périodique
Neurobiology of Aging
Auteur(s)
Wessel J.R., Ullsperger M., Obrig H., Villringer A., Quinque E., Schroeter M.L., Bretschneider K.J., Arelin K., Roggenhofer E., Frisch S., Klein T.A.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
38
Pages
205-213
Langue
anglais
Résumé
In humans, action errors and perceptual novelty elicit activity in a shared frontostriatal brain network, allowing them to adapt their ongoing behavior to such unexpected action outcomes. Healthy and pathologic aging reduces the integrity of white matter pathways that connect individual hubs of such networks and can impair the associated cognitive functions. Here, we investigated whether structural disconnection within this network because of small-vessel disease impairs the neural processes that subserve motor slowing after errors and novelty (post-error slowing, PES; post-novel slowing, PNS). Participants with intact frontostriatal circuitry showed increased right-lateralized beta-band (12-24 Hz) synchrony between frontocentral and frontolateral electrode sites in the electroencephalogram after errors and novelty, indexing increased neural communication. Importantly, this synchrony correlated with PES and PNS across participants. Furthermore, such synchrony was reduced in participants with frontostriatal white matter damage, in line with reduced PES and PNS. The results demonstrate that behavioral change after errors and novelty result from coordinated neural activity across a frontostriatal brain network and that such cognitive control is impaired by reduced white matter integrity.
Pubmed
Web of science
Création de la notice
19/02/2016 20:52
Dernière modification de la notice
03/03/2018 14:32
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