Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Les bases moléculaires de l'obésité : vers de nouvelles thérapeutiques ?
[Obesity: Molecular basis and therapeutic targets]
Obesity is an increasingly serious health problem, and is highly associated with insulin-resistance and dyslipidemia. The mechanisms involved in the development of this disorder are still poorly understood, although significant progress has been recently made in the elucidation of their molecular basis. The major causes leading to obesity are defects in the regulation of fat metabolism. Several mutations identified in different animal models have unveiled the roles of a number of genes in the regulation of energy balance. These dicoveries, together with the fact that some of these mutations have been found in humans, have lead to the conclusion that obesity is due to nutritional or environmental factors, but also involves genetic factors. A number of important peripheric factors participate in the regulation processes, such as the adipocyte-specific hormone leptin, and the nuclear homone receptors PPARs. A general scheme can now be drawn which includes some key factors and their respective interactions.
leptin (endogenous compound), peroxisome proliferator activated receptor (endogenous compound), cell nucleus receptor (endogenous compound), hormone receptor (endogenous compound), tumor necrosis factor alpha (endogenous compound), uncoupling protein 1 (endogenous compound), uncoupling protein 2 (endogenous compound), uncoupling protein 3 (endogenous compound), obesity (etiology) , adipocyte, disease association, dyslipidemia, energy balance, environmental factor, gene mutation, heredity, human, insulin resistance, lipid metabolism, nonhuman, nutrition, review
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