MLVA-typing on Streptococcus pneumoniae serotype 1 isolated from meningitis cases in Niger before the introduction of PCV-13 revealed a low genetic diversity.
Details
Serval ID
serval:BIB_1C2A488983A1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
MLVA-typing on Streptococcus pneumoniae serotype 1 isolated from meningitis cases in Niger before the introduction of PCV-13 revealed a low genetic diversity.
Journal
Transactions of the Royal Society of Tropical Medicine and Hygiene
ISSN
1878-3503 (Electronic)
ISSN-L
0035-9203
Publication state
Published
Issued date
07/2015
Peer-reviewed
Oui
Volume
109
Number
7
Pages
477-480
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
Serotype 1 was the most prevalent pneumococcal meningitis serotype encountered in Niger over the period 2003-2011 (pre-vaccination era), accounting for 45.3% of infections.
Multiple locus VNTR analysis (MLVA) was used to create a genotypic snapshot of a representative subset of the pneumococcal population of serotype 1.
MLVA using 16 markers revealed a homogeneous genetic background of pneumococci serotype 1 from Niger, which clustered with few serotype 1 pneumococci from some African countries, while other African countries displayed different clonal complexes. DNA from Niger and from other African countries were different from pneumococci serotype 1 from European countries.
MLVA-typing revealed a low genetic diversity among pneumococci serotype 1 from meningitis cases in Niger in the pre-vaccination era.
Multiple locus VNTR analysis (MLVA) was used to create a genotypic snapshot of a representative subset of the pneumococcal population of serotype 1.
MLVA using 16 markers revealed a homogeneous genetic background of pneumococci serotype 1 from Niger, which clustered with few serotype 1 pneumococci from some African countries, while other African countries displayed different clonal complexes. DNA from Niger and from other African countries were different from pneumococci serotype 1 from European countries.
MLVA-typing revealed a low genetic diversity among pneumococci serotype 1 from meningitis cases in Niger in the pre-vaccination era.
Keywords
Genetic Variation, Genotype, Humans, Meningitis/microbiology, Minisatellite Repeats/genetics, Multilocus Sequence Typing/methods, Niger/epidemiology, Pneumococcal Infections/microbiology, Pneumococcal Infections/prevention & control, Pneumococcal Vaccines/therapeutic use, Prevalence, Serotyping, Streptococcus pneumoniae/classification, Streptococcus pneumoniae/genetics, Streptococcus pneumoniae/isolation & purification, Genetic diversity, Multiple locus VNTR analysis, Niger, Serotype 1, Streptococcus pneumoniae
Pubmed
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Create date
12/08/2022 14:26
Last modification date
03/05/2023 9:04
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